Paraoxonase Role in Human Neurodegenerative Diseases

被引：36
作者：
Reichert, Cadiele Oliana [1 ]
Levy, Debora [1 ]
Bydlowski, Sergio P. [1 ,2 ]
机构：
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Lipids Oxidat & Cell Biol Grp, Lab Immunol LIM19,Heart Inst InCor,Fac Med, BR-05403900 Sao Paulo, Brazil
[2] CNPq, Inst Nacl Ciencia & Tecnol Med Regenerat INCT Reg, BR-21941902 Rio De Janeiro, Brazil
来源：
ANTIOXIDANTS | 2021年 / 10卷 / 01期
关键词：
paraoxonases; oxidative stress; multiple sclerosis; amyotrophic lateral sclerosis; Alzheimer’ s disease; Parkinson’ ONSET ALZHEIMERS-DISEASE; PROGRESSIVE MULTIPLE-SCLEROSIS; AMYOTROPHIC-LATERAL-SCLEROSIS; MILD COGNITIVE IMPAIRMENT; PON1 GENE POLYMORPHISMS; PARKINSONS-DISEASE; ARYLESTERASE ACTIVITY; CEREBROSPINAL-FLUID; SERUM PARAOXONASE; OXIDATIVE STRESS;
D O I：
10.3390/antiox10010011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes. The PONs genetic cluster is made up of three members (PON1, PON2, PON3) that share a structural homology, located adjacent to chromosome seven. The most studied enzyme is PON1, which is associated with high density lipoprotein (HDL), having paraoxonase, arylesterase and lactonase activities. Due to these characteristics, the enzyme PON1 has been associated with the development of neurodegenerative diseases. Here we update the knowledge about the association of PON enzymes and their polymorphisms and the development of multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD).
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页码：1 / 26
页数：26
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