Drugging the undruggabl: targeting challenging E3 ligases for personalized medicine

被引：25
作者：
Galdeano, Carles [1 ]
机构：
[1] Univ Barcelona, Facultat Farmacia Ciencies Alimentacio, Inst Biomed IBUB, Av Joan XXIII 27-31, Barcelona 08028, Spain
来源：
FUTURE MEDICINAL CHEMISTRY | 2017年 / 9卷 / 04期
关键词：
E3; ligases; personalized medicine; protein-protein interactions; undruggable targets; UBIQUITIN LIGASE; SUBSTRATE RECOGNITION; SMALL MOLECULES; DISCOVERY; COMPLEX; SYSTEM;
D O I：
10.4155/fmc-2017-0009
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A balanced risk/gain assessment should be considered before starting a drug discovery project aiming to target E3 ligases and, crucially, the amount of k-nowledge for a given E3 ligase can foretell the chances of success.
引用
收藏
页码：347 / 350
页数：4
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