Hormones in the naso-oropharynx: endocrine modulation of taste and smell

被引：50

作者：

Martin, Bronwen ^{[2
]}

Maudsley, Stuart ^{[3
]}

White, Caitlin M. ^{[2
]}

Egan, Josephine M. ^{[1
]}

机构：

[1] NIA, Clin Invest Lab, Intramural Res Program, Baltimore, MD 21224 USA

[2] NIA, Neurosci Lab, Intramural Res Program, Baltimore, MD 21224 USA

[3] NIA, Receptor Pharmacol Unit, Intramural Res Program, Baltimore, MD 21224 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2009年 / 20卷 / 04期

关键词：

VASOACTIVE-INTESTINAL-PEPTIDE; GLUCAGON-LIKE PEPTIDE-1; LEPTIN RECEPTOR; NEUROPEPTIDE-Y; SWEET TASTE; ULTRASTRUCTURAL-LOCALIZATION; COEXPRESSION PATTERNS; POSITIONAL CLONING; ENSHEATHING CELLS; ALPHA-GUSTDUCIN;

D O I：

10.1016/j.tem.2009.01.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Olfaction and gustation are important sensory modalities for locating food and for determining which foodstuffs to ingest. It is becoming apparent that there is a strong link between olfaction, gustation and metabolic control. Because endocrine signaling in the naso-oropharynx is likely to influence food intake, satiety and general metabolic control, it is important to examine some of the major hormones that play an integral part in energy homeostasis. Here, we provide an overview of the main endocrine factors known to be present in the naso-oropharynx and discuss their functional roles in maintaining metabolic function. Gaining a greater appreciation of how flavor perception is linked to peripheral metabolism could lead to novel therapeutic strategies for obesity and lifestyle-related diseases.

引用

页码：163 / 170

页数：8

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