Puberty and prenatal growth

被引：52
作者：
Ibanez, Lourdes
de Zegher, Francis
机构：
[1] Univ Barcelona, Endocrinol Unit, Hosp Sant Joan de Deu, Barcelona 08950, Spain
[2] Univ Louvain, Louvain, Belgium
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2006年 / 254卷
关键词：
intrauterine growth retardation; adrenarche; pubarche; puberty; insulin; metformin; growth hormone;
D O I：
10.1016/j.mce.2006.04.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
There is increasing evidence for a link between puberty and prenatal growth. Here we highlight a selection of pubertal characteristics in children who were born small-for-gestational-age (SGA). Boys born SGA are at risk for high FSH and low inhibin B levels, and a small testicular volume in adolescence. In girls born SGA, the age at pubertal onset and the age at menarche-are advanced by about 5-10 months; prenatal growth restraint may be associated with higher FSH levels and with small internal genitalia in adolescence. The ovulation rate was found to be low in SGA adolescents, and an insulin-sensitizing therapy was capable of raising this low ovulation rate. Menarche is definitely advanced in SGA girls with precocious pubarche. Current evidence suggests that insulin resistance is a key mechanism linking a post-SGA state to early menarche; hence, insulin sensitization may become a valid approach to prevent early menarche and early growth arrest in SGA girls. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：22 / 25
页数：4
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