Periodontal disease and hemolysis in glucose-6-phosphate dehydrogenase deficiency: Is there a nexus?

被引：0

作者：

Singh, Neelesh ^{[1
]}

Uppoor, Ashita ^{[2
]}

Rajendran, Valliammai ^{[2
]}

Naik, Dilip G. ^{[2
]}

机构：

[1] Maharana Pratap Dent Coll & Hosp, Dept Periodontol, Kanpur, Uttar Pradesh, India

[2] Manipal Acad Higher Educ, Manipal Coll Dent Sci, Dept Periodontol, Manipal 576104, Karnataka, India

来源：

JOURNAL OF ORAL BIOSCIENCES | 2019年 / 61卷 / 02期

关键词：

G6PD deficiency; Periodontal infection; Oxidative stress; Hemolysis; REACTIVE OXYGEN METABOLITES; TOTAL ANTIOXIDANT CAPACITY; GINGIVAL CREVICULAR FLUID; LIPID-PEROXIDATION; OXIDATIVE STRESS; PERIPHERAL-BLOOD; SERUM; NEUTROPHILS; INJURY; SALIVA;

D O I：

10.1016/j.job.2019.03.001

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an erythrocyte enzyme defect that amplifies the susceptibility of erythrocytes to oxidative stress due to excessive levels of reactive oxygen species. Consequently, erythrocyte destruction and hemolysis occur. Highlight: The possible mechanism of oxidative stress-mediated destruction of erythrocytes in G6PD deficient individuals induced by periodontal infection is highlighted. Conclusion: Periodontal diseases feature systemic loading of reactive oxygen species, and they may increase the risk of hemolysis in individuals with G6PD deficiency. (C) 2019 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved.

引用

页码：129 / 133

页数：5

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