The Costimulatory Pathways and T Regulatory Cells in Ischemia-Reperfusion Injury: A Strong Arm in the Inflammatory Response?

被引：8

作者：

de Ramon, Laura ^{[1
]}

Guiteras, Jordi ^{[1
]}

Guiteras, Roser ^{[1
]}

Cruzado, Josep M. ^{[1
,2
]}

Grinyo, Josep M. ^{[1
,2
]}

Torras, Juan ^{[1
,2
]}

机构：

[1] Univ Barcelona, Expt & Translat Lab Nephrol, Clin Sci Dept, Inst Invest Biomed Bellvitge IDIBELL, Barcelona 08907, Spain

[2] Hosp Univ Bellvitge, Barcelona 08907, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 05期

关键词：

costimulatory molecules; ischemia; regulatory T cells; GRAFT ARTERIAL-DISEASE; BLOOD DENDRITIC CELLS; B-CELLS; MONOCLONAL-ANTIBODY; ISCHEMIA/REPERFUSION INJURY; PATHOPHYSIOLOGICAL ROLE; CD28; COSTIMULATION; PD-1; PATHWAY; CD137; LIGAND; CD40;

D O I：

10.3390/ijms19051283

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Costimulatory molecules have been identified as crucial regulators in the inflammatory response in various immunologic disease models. These molecules are classified into four different families depending on their structure. Here, we will focus on various ischemia studies that use costimulatory molecules as a target to reduce the inherent inflammatory status. Furthermore, we will discuss the relevant role of T regulatory cells in these inflammatory mechanisms and the costimulatory pathways in which they are involved.

引用

页数：14

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