Palladium(0)-Catalyzed Heck Reaction/C-H Activation/Amination Sequence with Diaziridinone: A Facile Approach to Indolines

被引：125
作者：
Zheng, Huaiji [1 ]
Zhu, Yingguang [1 ]
Shi, Yian [1 ]
机构：
[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 42期
基金：
美国国家卫生研究院;
关键词：
CH activation; cyclization; heterocycles; palladium; synthetic methods; BOND FORMATION; PD(0)-CATALYZED DIAMINATION; PD(II)-CATALYZED AMINATION; CONJUGATED DIENES; TERMINAL OLEFINS; ARYL HALIDES; PALLADIUM; FUNCTIONALIZATION; DERIVATIVES; C(SP(3))-H;
D O I：
10.1002/anie.201405365
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Indolines are important moieties present in various biologically significant molecules and have attracted considerable attention in synthetic chemistry. This paper describes a Heck reaction/CH activation/amination sequence for forming indolines using di-tert-butyldiaziridinone. The reaction process likely proceeds via a pallada(II)cycle, which is converted into an indoline by oxidative addition to the diaziridinone and two subsequent CN bond formations.
引用
收藏
页码：11280 / 11284
页数：5
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