A Single-Cell Window into Pancreas Cancer Fibroblast Heterogeneity

被引：14

作者：

Belle, Jad I. ^{[1
]}

DeNardo, David G. ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pathol & Immunol, Div Oncol, St Louis, MO USA

来源：

CANCER DISCOVERY | 2019年 / 9卷 / 08期

关键词：

D O I：

10.1158/2159-8290.CD-19-0576

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer-associated fibroblasts (CAF) have been implicated in diverse and sometimes divergent tumor modulatory processes that can be explained only by the existence of heterogeneous CAF subsets. In this issue of Cancer Discovery, Elyada and colleagues utilize single-cell transcriptomics to resolve CAF heterogeneity in pancreatic ductal adenocarcinoma and identify a novel antigen-presenting CAF population.

引用

页码：1001 / 1002

页数：2