Effect of crude extracts of Erythrina americana Mill. on aggressive behavior in rats

被引：33
作者：
Garín-Aguilar, ME
Luna, JER
Soto-Hernández, M
del Toro, GV
Vázquez, MM
机构：
[1] Colegio Postgrad, Programa Bot, Montecillo 56230, Edo De Mex, Mexico
[2] Univ Nacl Autonoma Mexico, ENEP Iztacala, Tlalnepantla 54690, Edo De Mex, Mexico
[3] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 69卷 / 02期
关键词：
Erythrina americana; alkaloids; pharmacology; aggression;
D O I：
10.1016/S0378-8741(99)00121-X
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three alkaloid fractions were obtained from seeds of Erythrina americana: free alkaloids in hexane, free alkaloids in methanol and liberated alkaloids. The pharmacological evaluation of these fractions on rats showed that, administered in a dose of 3 mg/kg, the three fractions diminished the aggressive behavior. This is comparable when diazepam is used as a control. An interaction between the cholinergic and GABAergic system could be suggested. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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页码：189 / 196
页数：8
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