Distinctive RNA Expression Profiles in Blood Associated With Alzheimer Disease After Accounting for White Matter Hyperintensities

被引：44

作者：

Bai, Zhouxian ^{[1
,2
]}

Stamova, Boryana ^{[3
,4
]}

Xu, Huichun ^{[3
,4
,6
]}

Ander, Bradley P. ^{[3
,4
]}

Wang, Jiajia ^{[1
,2
]}

Jickling, Glen C. ^{[3
,4
]}

Zhan, Xinhua ^{[3
,4
]}

Liu, DaZhi ^{[3
,4
]}

Han, Guangchun ^{[1
,2
]}

Jin, Lee-Way ^{[3
,4
,5
]}

DeCarli, Charles ^{[5
]}

Lei, Hongxing ^{[1
]}

Sharp, Frank R. ^{[3
,4
]}

机构：

[1] Chinese Acad Sci, CAS Key Lab Genome Sci & Informat, Beijing Inst Genom, Beijing, Peoples R China

[2] Univ Chinese Acad Sci, CAS Key Lab Genome Sci & Informat, Beijing, Peoples R China

[3] Univ Calif Davis, Sch Med, Dept Neurol, Sacramento, CA 95817 USA

[4] Univ Calif Davis, Sch Med, MIND Inst, Sacramento, CA 95817 USA

[5] Univ Calif Davis, Sch Med, Alzheimers Dis Ctr, Sacramento, CA 95817 USA

[6] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2014年 / 28卷 / 03期

关键词：

Alzheimer disease; RNA; white matter hyperintensities; blood; brain; A-BETA; MATRIX METALLOPROTEINASES; GENE-EXPRESSION; BRAIN-BARRIER; NEPRILYSIN; TGF-BETA-1; PROTEIN; IMPAIRMENT; ACTIVATION; CLEARANCE;

D O I：

10.1097/WAD.0000000000000022

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Defining the RNA transcriptome in Alzheimer Disease (AD) will help understand the disease mechanisms and provide biomarkers. Though the AD blood transcriptome has been studied, effects of white matter hyperintensities (WMH) were not considered. This study investigated the AD blood transcriptome and accounted for WMH. Methods: RNA from whole blood was processed on whole-genome microarrays. Results: A total of 293 probe sets were differentially expressed in AD versus controls, 5 of which were significant for WMH status. The 288 AD-specific probe sets classified subjects with 87.5% sensitivity and 90.5% specificity. They represented 188 genes of which 29 have been reported in prior AD blood and 89 in AD brain studies. Regulated blood genes included MMP9, MME (Neprilysin), TGF beta 1, CA4, OCLN, ATM, TGM3, IGFR2, NOV, RNF213, BMX, LRRN1, CAMK2G, INSR, CTSD, SORCS1, SORL1, and TANC2. Conclusions: RNA expression is altered in AD blood irrespective of WMH status. Some genes are shared with AD brain.

引用

页码：226 / 233

页数：8

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