Palladium-Catalyzed Decarboxylative Trifluoroethylation of Aryl Alkynyl Carboxylic Acids

被引：64

作者：

Hwang, Jinil ^{[1
]}

Park, Kyungho ^{[1
]}

Choe, Juseok ^{[1
]}

Min, Hongkeun ^{[1
]}

Song, Kwang Ho ^{[2
]}

Lee, Sunwoo ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Chem, Kwangju 500757, South Korea

[2] Korea Univ, Dept Chem & Biol Engn, Seoul 136713, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

TERMINAL ALKYNES; ELECTROPHILIC TRIFLUOROMETHYLATION; OXIDATIVE TRIFLUOROMETHYLATION; MEDIATED FLUORINATION; UNACTIVATED ALKENES; COUPLING REACTIONS; HALIDES; AMINOFLUORINATION; STRATEGY; CARBON;

D O I：

10.1021/jo5003032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A trifluoroethylation of alkynes through a palladium-catalyzed decarboxylative coupling reaction was developed. When alkynyl carboxylic acids and ICH2CF3 were allowed to react with [Pd(eta(3)-allyl)Cl](2)/XantPhos and Cs2CO3 in N,N-dimethylformamide (DMF) at 80 degrees C for 1 h, the desired products were formed in good yields. This catalytic system showed high functional group tolerance.

引用

页码：3267 / 3271

页数：5

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