Quantitative analyses of matrix metalloproteinase activity after traumatic brain injury in adult rats

被引：68

作者：

Hayashi, Takuro ^{[1
]}

Kaneko, Yuji ^{[1
]}

Yu, SeongJin ^{[1
]}

Bae, EunKyung ^{[1
]}

Stahl, Christine E. ^{[2
]}

Kawase, Takeshi ^{[3
]}

van Loveren, Harry ^{[1
]}

Sanberg, Paul R. ^{[1
]}

Borlongan, Cesar V. ^{[1
]}

机构：

[1] Univ S Florida, Dept Neurosurg, 12906 Bruce B Downs Blvd MDC78, Tampa, FL 33612 USA

[2] Dwight D Eisenhower Army Med Ctr, Dept Internal Med, Ft Gordon, GA 30905 USA

[3] Keio Univ, Dept Neurosurg, Shinjuku Ku, Tokyo 1608582, Japan

来源：

BRAIN RESEARCH | 2009年 / 1280卷

关键词：

Head injury; MMP-9; Cortex; Immunohistochemistry; Quantitative real-time PCR; CONTROLLED CORTICAL IMPACT; EXPRESSION; MATRIX-METALLOPROTEINASE-9; SYNAPTOGENESIS; THERAPY; DEATH; MICE;

D O I：

10.1016/j.brainres.2009.05.040

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent laboratory evidence implicates matrix metalloproteinases (MMPs) as playing a pivotal role in ischemic and traumatic brain injuries (TBI). Here, quantitative real-time PCR analyses revealed that brains from TBI rats displayed significantly elevated MMP-9 expression at 24 h post-TBI, which remained upregulated at least until 48 h after injury. Immunohistochemical analyses similarly revealed significantly increased MMP-9 immunoreactivity at 24 and 48 h post-TBI. These results demonstrate that alterations in MMPs (i.e., MMP-9) commenced immediately after TBI, suggesting that treatment strategies designed to maintain MMP integrity should be initiated in the acute phase of injury. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：172 / 177

页数：6

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