Predicting APL lethal bleeding in the ATRA era

被引:10
作者
Falanga, Anna [1 ]
机构
[1] Hosp Papa Giovanni XXIII, Bergamo, Italy
关键词
ACUTE PROMYELOCYTIC LEUKEMIA;
D O I
10.1182/blood-2017-02-763490
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In this issue of Blood, Mantha and colleagues advance our understanding of risk factors for early hemorrhagic death (HD) in patients with acute promyelocytic leukemia (APL) in the all-trans retinoic acid (ATRA) era. 1 Analysis of HD risk factors in a large series of ATRA-treated patients convincingly shows that high white blood cell (WBC) count is an independent predictor of early HD. The results help to construct a profile of patients at high-risk for bleeding.
引用
收藏
页码:1739 / 1740
页数:2
相关论文
共 8 条
[1]   Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death [J].
Altman, Jessica K. ;
Rademaker, Alfred ;
Cull, Elizabeth ;
Weitner, Bing Bing ;
Ofran, Yishai ;
Rosenblat, Todd L. ;
Haidau, Augustin ;
Park, Jae H. ;
Ram, Sharona Lee ;
Orsini, James M., Jr. ;
Sandhu, Sonia ;
Catchatourian, Rosalind ;
Trifilio, Steven M. ;
Adel, Nelly G. ;
Frankfurt, Olga ;
Stein, Eytan M. ;
Mallios, George ;
Deblasio, Tony ;
Jurcic, Joseph G. ;
Nimer, Stephen ;
Peterson, LoAnn C. ;
Kwaan, Hau C. ;
Rowe, Jacob M. ;
Douer, Dan ;
Tallman, Martin S. .
LEUKEMIA RESEARCH, 2013, 37 (09) :1004-1009
[2]   Thrombo-hemorrhagic deaths in acute promyelocytic leukemia [J].
Breccia, Massimo ;
Lo Coco, Francesco .
THROMBOSIS RESEARCH, 2014, 133 :S112-S116
[3]   LOSS OF BLAST CELL PROCOAGULANT ACTIVITY AND IMPROVEMENT OF HEMOSTATIC VARIABLES IN PATIENTS WITH ACUTE PROMYELOCYTIC LEUKEMIA ADMINISTERED ALL-TRANS-RETINOIC ACID [J].
FALANGA, A ;
IACOVIELLO, L ;
EVANGELISTA, V ;
BELOTTI, D ;
CONSONNI, R ;
DORAZIO, A ;
ROBBA, L ;
DONATI, MB ;
BARBUI, T .
BLOOD, 1995, 86 (03) :1072-1081
[4]   The coagulopathy in acute promyelocytic leukaemia - What have we learned in the past twenty years [J].
Kwaan, Hau C. ;
Barnett, Marjorie C. ;
Cull, Elizabeth H. .
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2014, 27 (01) :11-18
[5]   Determinants of fatal bleeding during induction therapy for acute promyelocytic leukemia in the ATRA era [J].
Mantha, Simon ;
Goldman, Debra A. ;
Devlin, Sean M. ;
Lee, Ju-Whei ;
Zannino, Diana ;
Collins, Marnie ;
Douer, Dan ;
Iland, Harry J. ;
Litzow, Mark R. ;
Stein, Eytan M. ;
Appelbaum, Frederick R. ;
Larson, Richard A. ;
Stone, Richard ;
Powell, Bayard L. ;
Geyer, Susan ;
Laumann, Kristina ;
Rowe, Jacob M. ;
Erba, Harry ;
Coutre, Steven ;
Othus, Megan ;
Park, Jae H. ;
Wiernik, Peter H. ;
Tallman, Martin S. .
BLOOD, 2017, 129 (13) :1763-1767
[6]   Bleeding and thrombosis in acute leukemia: What does the future of therapy look like? [J].
Rickles, Frederick R. ;
Falanga, Anna ;
Montesinos, Pau ;
Sanz, Miguel A. ;
Brenner, Benjamin ;
Barbui, Tiziano .
THROMBOSIS RESEARCH, 2007, 120 :S99-S106
[7]   Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet [J].
Sanz, Miguel A. ;
Grimwade, David ;
Tallman, Martin S. ;
Lowenberg, Bob ;
Fenaux, Pierre ;
Estey, Elihu H. ;
Naoe, Tomoki ;
Lengfelder, Eva ;
Buechner, Thomas ;
Doehner, Hartmut ;
Burnett, Alan K. ;
Lo-Coco, Francesco .
BLOOD, 2009, 113 (09) :1875-1891
[8]  
Tallman Martin S, 2005, Leuk Res, V29, P347, DOI 10.1016/j.leukres.2004.04.021