A near-infrared responsive germanium complex of Ge/GeO2 for targeted tumor phototherapy

被引：11

作者：

Gao, Yan ^{[1
]}

Wang, Siqi ^{[1
]}

Yang, Chunyu ^{[1
]}

An, Na ^{[1
]}

Liu, Zhao ^{[2
]}

Yan, Mei ^{[1
]}

Guo, Chongshen ^{[1
]}

机构：

[1] Harbin Inst Technol, Schaal Chem & Chem Engn, Harbin 150080, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Dept Ultrasound, Canc Hosp, Harbin 150080, Heilongjiang, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2019年 / 7卷 / 33期

基金：

中国国家自然科学基金;

关键词：

ENHANCED PERMEABILITY; AQUEOUS SYNTHESIS; HIGHLY EFFICIENT; THERAPY; NANOPARTICLES; AGENT; BIOCOMPATIBILITY; NANOCRYSTALS; MACROPHAGES; RETENTION;

D O I：

10.1039/c9tb00548j

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The development of photoactive nanomaterials with high biocompatibility for targeted tumor phototherapy is of great significance for antitumor applications; this study presents a novel phototherapeutic agent, the Ge/GeO2 complex, which shows broad photoabsorption in the near infrared (NIR) region. As a result, it can synchronously produce reactive oxygen species (ROS) and heat under NIR irradiation. After being loaded onto macrophages, Ge/GeO2 could be delivered to tumors in a targeted fashion. Combining the abovementioned merits together, macrophage-loaded Ge/GeO2 realized in vivo synergetic photothermal and photodynamic outcomes to completely remove solid tumors in mice via intravenous administration. In this study, B-ultrasonography was also employed to monitor the tumor evolution after phototherapy, revealing a sequential process of tumor necrosis, liquefaction/softening, and finally disappearance. In addition, Ge/GeO2 proposed in this study shows negligible cytotoxicity and hematotoxicity, especially after being loaded onto macrophages.

引用

页码：5056 / 5064

页数：9

共 48 条

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