Synthesis of 7-deaza-8-bromo cyclic adenosine 5'-diphosphate ribose: The first hydrolysis resistant antagonist at the cADPR receptor

被引：15

作者：

Bailey, VC

Sethi, JK

Galione, A

Potter, BVL

机构：

[1] UNIV BATH,SCH PHARM & PHARMACOL,DEPT MED CHEM,BATH BA2 7AY,AVON,ENGLAND

[2] UNIV OXFORD,DEPT PHARMACOL,OXFORD OX1 3QT,ENGLAND

来源：

CHEMICAL COMMUNICATIONS | 1997年 / 07期

关键词：

D O I：

10.1039/a700336f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

7-Deaza-8-bromo cyclic adenosine 5'-diphosphate ribose is synthesised from 7-deazaadenosine via 7-deaza-8-bromo nicotinamide adenine dinucleotide; it is both a more potent antagonist than the 8-bromo derivative and has the advantage of chemical and enzymatic hydrolytic stability.

引用

收藏

页码：695 / 696

页数：2

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