Recent advances in cancer treatment by iron chelators

被引：60

作者：

Corce, Vincent ^{[1
]}

Gouin, Sebastien G. ^{[1
]}

Renaud, Stephanie ^{[2
,3
]}

Gaboriau, Francois ^{[2
,3
]}

Deniaud, David ^{[1
]}

机构：

[1] LUNAM Univ, CEISAM, UMR CNRS 6230, UFR Sci & Tech, F-44322 Nantes 3, France

[2] CHRU Pontchaillou, INSERM, UMR 991, F-35033 Rennes, France

[3] Univ Rennes 1, F-35043 Rennes, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 02期

关键词：

Iron; Metal chelators; 8-Hydroxyquinoline; Tumor vectorisation; Polyamine; PYRIDOXAL ISONICOTINOYL HYDRAZONE; POLYAMINE TRANSPORT-SYSTEM; ANTIPROLIFERATIVE AGENTS; BIOLOGICAL-PROPERTIES; OVERLOAD DISEASE; O-TRENSOX; FE-III; CELLS; DESIGN; DEFERIPRONE;

D O I：

10.1016/j.bmcl.2015.11.094

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The development of new therapeutic alternatives for cancers is a major public health priority. Among the more promising approaches, the iron depletion strategy based on metal chelation in the tumoral environment has been particularly studied in recent decades. After a short description of the importance of iron for cancer cell proliferation, we will review the different iron chelators developed as potential chemotherapeutics. Finally, the recent efforts to vectorize the chelating agents specifically in the microtumoral environment will be discussed in detail. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：251 / 256

页数：6

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