The HIV care cascade in Switzerland: reaching the UNAIDS/WHO targets for patients diagnosed with HIV

被引:69
作者
Kohler, Philipp [1 ,2 ]
Schmidt, Axel J. [1 ,3 ,4 ]
Cavassini, Matthias [5 ]
Furrer, Hansjakob [6 ]
Calmy, Alexandra [7 ]
Battegay, Manuel [8 ]
Bernasconi, Enos [9 ]
Ledergerber, Bruno [2 ]
Vernazza, Pietro [1 ]
机构
[1] Cantonal Hosp St Gallen, Div Infect Dis & Infect Control, St Gallen, Switzerland
[2] Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland
[3] Fed Off Publ Hlth, Communicable Dis Div, Bern, Switzerland
[4] London Sch Hyg & Trop Med, Dept Social & Environm Hlth Res, Lausanne, Switzerland
[5] Univ Lausanne Hosp, Div Infect Dis & Hosp Epidemiol, Lausanne, Switzerland
[6] Univ Hosp Bern, Univ Clin Infect Dis, Bern, Switzerland
[7] Univ Hosp Geneva, HIV Unit, Geneva, Switzerland
[8] Cantonal Hosp St Gallen, Div Infect Dis & Infect Control, St Gallen, Switzerland
[9] Osped Reg, Lugano, Switzerland
基金
瑞士国家科学基金会;
关键词
care; cascade; epidemiology; HIV; HIV prevalence; Switzerland; WHO targets; ANTIRETROVIRAL THERAPY; INFECTION; PREVENTION; SUPPRESSION;
D O I
10.1097/QAD.0000000000000878
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objectives: To describe the HIV care cascade for Switzerland in the year 2012. Design/methods: Six levels were defined: (i) HIV-infected, (ii) HIV-diagnosed, (iii) linked to care, (iv) retained in care, (v) on antiretroviral treatment (ART), and (vi) with suppressed viral load. We used data from the Swiss HIV Cohort Study (SHCS) complemented by a nationwide survey among SHCS physicians to estimate the number of HIV-patients not registered in the cohort. We also used Swiss ART sales data to estimate the number of patients treated outside the SHCS network. Based on the number of patients retained in care, we inferred the estimates for levels (i) to (iii) from previously published data. Results: We estimate that (i) 15200 HIV-infected individuals lived in Switzerland in 2012 (margins of uncertainty, 13400-19300). Of those, (ii) 12300 (81%) were diagnosed, (iii) 12200 (80%) linked, and (iv) 11900 (79%) retained in care. Broadly based on SHCS network data, (v) 10800 (71%) patients were receiving ART, and (vi) 10400 (68%) had suppressed (<200 copies/ml) viral loads. The vast majority (95%) of patients retained in care were followed within the SHCS network, with 76% registered in the cohort. Conclusion: Our estimate for HIV-infected individuals in Switzerland is substantially lower than previously reported, halving previous national HIV prevalence estimates to 0.2%. In Switzerland in 2012, 91% of patients in care were receiving ART, and 96% of patients on ART had suppressed viral load, meeting recent UNAIDS/WHO targets. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
引用
收藏
页码:2509 / 2515
页数:7
相关论文
共 25 条
[1]  
Adam Barry D, 2011, J Int AIDS Soc, V14 Suppl 2, pS2, DOI 10.1186/1758-2652-14-S2-S2
[2]  
[Anonymous], POPULATION SIZE AND
[3]  
[Anonymous], SWISS MED WKLY
[4]  
[Anonymous], 2014, 90 90 90 AMB TREATM
[5]  
[Anonymous], GLOB REP
[6]   The late diagnosis and consequent short-term mortality of HIV-infected heterosexuals (England and Wales, 2000-2004) [J].
Chadborn, Timothy R. ;
Delpech, Valerie C. ;
Sabin, Caroline A. ;
Sinka, Katy ;
Evans, Barry G. .
AIDS, 2006, 20 (18) :2371-2379
[7]   HIV Treatment as Prevention: Debate and Commentary-Will Early Infection Compromise Treatment-as-Prevention Strategies? [J].
Cohen, Myron S. ;
Dye, Christopher ;
Fraser, Christophe ;
Miller, William C. ;
Powers, Kimberly A. ;
Williams, Brian G. .
PLOS MEDICINE, 2012, 9 (07)
[8]   Prevention of HIV-1 Infection with Early Antiretroviral Therapy [J].
Cohen, Myron S. ;
Chen, Ying Q. ;
McCauley, Marybeth ;
Gamble, Theresa ;
Hosseinipour, Mina C. ;
Kumarasamy, Nagalingeswaran ;
Hakim, James G. ;
Kumwenda, Johnstone ;
Grinsztejn, Beatriz ;
Pilotto, Jose H. S. ;
Godbole, Sheela V. ;
Mehendale, Sanjay ;
Chariyalertsak, Suwat ;
Santos, Breno R. ;
Mayer, Kenneth H. ;
Hoffman, Irving F. ;
Eshleman, Susan H. ;
Piwowar-Manning, Estelle ;
Wang, Lei ;
Makhema, Joseph ;
Mills, Lisa A. ;
de Bruyn, Guy ;
Sanne, Ian ;
Eron, Joseph ;
Gallant, Joel ;
Havlir, Diane ;
Swindells, Susan ;
Ribaudo, Heather ;
Elharrar, Vanessa ;
Burns, David ;
Taha, Taha E. ;
Nielsen-Saines, Karin ;
Celentano, David ;
Essex, Max ;
Fleming, Thomas R. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (06) :493-505
[9]   Essential Components of Effective HIV Care: A Policy Paper of the HIV Medicine Association of the Infectious Diseases Society of America and the Ryan White Medical Providers Coalition [J].
Gallant, Joel E. ;
Adimora, Adaora A. ;
Carmichael, J. Kevin ;
Horberg, Michael ;
Kitahata, Mari ;
Quinlivan, E. Byrd ;
Raper, James L. ;
Selwyn, Peter ;
Williams, Steven Bruce .
CLINICAL INFECTIOUS DISEASES, 2011, 53 (11) :1043-1050
[10]   The Spectrum of Engagement in HIV Care and its Relevance to Test-and-Treat Strategies for Prevention of HIV Infection [J].
Gardner, Edward M. ;
McLees, Margaret P. ;
Steiner, John F. ;
del Rio, Carlos ;
Burman, William J. .
CLINICAL INFECTIOUS DISEASES, 2011, 52 (06) :793-800