Advanced Squamous Cell Carcinoma of the Head and Neck: The Current Role of Cetuximab

被引：4

作者：

Granados-Garcia, Martin ^{[1
]}

Luis Aguilar-Ponce, Jose ^{[2
]}

Maldonado-Magos, Federico ^{[3
]}

De la Garza-Salazar, Jaime G. ^{[2
]}

机构：

[1] Inst Nacl Cancerol, Head & Neck Canc Dept, San Fernando 22,Col Secc 15, Mexico City 14400, DF, Mexico

[2] Inst Nacl Cancerol, Subdirect Internal Med, Mexico City, DF, Mexico

[3] Inst Nacl Cancerol, Subdirect Radiat Therapy, Mexico City, DF, Mexico

来源：

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY | 2016年 / 78卷 / 06期

关键词：

Head and neck cancer; Advanced squamous cell carcinoma of the head and neck; Chemoradiotherapy; Bioradiotherapy; Cetuximab; PLATINUM-BASED CHEMOTHERAPY; LOCALLY ADVANCED HEAD; QUALITY-OF-LIFE; RADIOTHERAPY PLUS CETUXIMAB; COOPERATIVE-ONCOLOGY-GROUP; PREVIOUSLY-IRRADIATED HEAD; PHASE-II MULTICENTER; INDUCED SKIN RASH; CANCER PATIENTS; 1ST-LINE TREATMENT;

D O I：

10.1159/000455891

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

We review clinical trials of squamous cell carcinoma of the head and neck (SCCHN) to address the current and potential uses of cetuximab (CTX). PubMed was reviewed to identify papers published between 2010 and 2016. The search terms used were "cetuximab" and "head and neck cancer." A total of 634 articles were identified. Phase II or III studies with CTX in patients with advanced SCCHN without treatment or with recurrent/metastatic tumors were selected. Forty-six registries were obtained. Information was critically reviewed and relevant information presented. As definitive treatment of advanced squamous cells carcinomas and as palliative treatment of recurrent/metastatic disease, CTX alone or associated with chemotherapy and/or radiotherapy is an alternative to chemoradiotherapy because of its distinct and favorable toxicity profile. (C) 2017 S. Karger AG, Basel

引用

页码：320 / 333

页数：14

共 55 条

[1] Correlation of cetuximab-induced skin rash and outcomes of solid tumor patients treated with cetwdmab: A systematic review and meta-analysis [J].

Abdel-Rahman, Omar ;

Fouad, Mona .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2015, 93 (02) :127-135

[2] A Phase 2 Trial of Induction nab-Paclitaxel and Cetuximab Given With Cisplatin and 5-Fluorouracil Followed by Concurrent Cisplatin and Radiation for Locally Advanced Squamous Cell Carcinoma of the Head and Neck [J].

Adkins, Douglas ;

Ley, Jessica ;

Trinkaus, Kathryn ;

Thorstad, Wade ;

Lewis, James, Jr. ;

Wildes, Tanya ;

Siegel, Barry A. ;

Dehdashti, Farrokh ;

Gay, Hiram ;

Mehan, Paul ;

Nussenbaum, Brian .

CANCER, 2013, 119 (04) :766-773

[3] Randomized Phase III Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Stage III to IV Head and Neck Carcinoma: RTOG 0522 [J].

Ang, K. Kian ;

Zhang, Qiang ;

Rosenthal, David I. ;

Nguyen-Tan, Phuc Felix ;

Sherman, Eric J. ;

Weber, Randal S. ;

Galvin, James M. ;

Bonner, James A. ;

Harris, Jonathan ;

El-Naggar, Adel K. ;

Gillison, Maura L. ;

Jordan, Richard C. ;

Konski, Andre A. ;

Thorstad, Wade L. ;

Trotti, Andy ;

Beitler, Jonathan J. ;

Garden, Adam S. ;

Spanos, William J. ;

Yom, Sue S. ;

Axelrod, Rita S. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (27) :2940-+

[4]

Argiris A, 2006, J CLIN ONCOL, V24, p298S

[5] Reirradiation With Cetuximab in Locoregional Recurrent and Inoperable Squamous Cell Carcinoma of the Head and Neck: Feasibility and First Efficacy Results [J].

Balermpas, Panagiotis ;

Keller, Christian ;

Hambek, Markus ;

Wagenblast, Jens ;

Seitz, Oliver ;

Roedel, Claus ;

Weiss, Christian .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 83 (03) :E377-E383

[6] Correlation Between the Severity of Cetuximab-Induced Skin Rash and Clinical Outcome for Head and Neck Cancer Patients: The RTOG Experience [J].

Bar-Ad, Voichita ;

Zhang, Qiang ;

Harari, Paul M. ;

Axelrod, Rita ;

Rosenthal, David I. ;

Trotti, Andy ;

Jones, Christopher U. ;

Garden, Adam S. ;

Song, Guobin ;

Foote, Robert L. ;

Raben, David ;

Shenouda, George ;

Spencer, Sharon A. ;

Harris, Jonathan ;

Quynh-Thu Le .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2016, 95 (05) :1346-1354

[7] Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck [J].

Baselga, J ;

Trigo, JM ;

Bourhis, J ;

Tortochaux, J ;

Cortés-Funes, H ;

Hitt, R ;

Gascón, P ;

Arnellal, N ;

Harstrick, A ;

Eckardt, A .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (24) :5568-5577

[8] Management of radiation dermatitis in patients receiving cetuximab and radiotherapy for locally advanced squamous cell carcinoma of the head and neck: proposals for a revised grading system and consensus management guidelines [J].

Bernier, J. ;

Russi, E. G. ;

Homey, B. ;

Merlano, M. C. ;

Mesia, R. ;

Peyrade, F. ;

Budach, W. .

ANNALS OF ONCOLOGY, 2011, 22 (10) :2191-2200

[9] Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): A comprehensive analysis by tumour site [J].

Blanchard, Pierre ;

Baujat, Bertrand ;

Holostenco, Victoria ;

Bourredjem, Abderrahmane ;

Baey, Charlotte ;

Bourhis, Jean ;

Pignon, Jean-Pierre .

RADIOTHERAPY AND ONCOLOGY, 2011, 100 (01) :33-40

[10] Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck [J].

Bonner, JA ;

Harari, PM ;

Giralt, J ;

Azarnia, N ;

Shin, DM ;

Cohen, RB ;

Jones, CU ;

Sur, R ;

Raben, D ;

Jassem, J ;

Ove, R ;

Kies, MS ;

Baselga, J ;

Youssoufian, H ;

Amellal, N ;

Rowinsky, EK ;

Ang, KK .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) :567-578

← 1 2 3 4 5 6 →