RETRACTED: Long non-coding RNA DLX6-AS1 acts as an oncogene by targeting miR-613 in ovarian cancer (Retracted Article)

被引：15
|
作者：
You, Q. [1 ]
Shi, H-Y [2 ]
Gong, C-F [1 ]
Tian, X-Y [1 ]
Li, S. [1 ]
机构：
[1] Harbin Med Univ, Dept Gynecol & Obstet, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China
[2] Qingdao Fuwai Cardiovasc Hosp, Dept Outpatient Gynecol, Qingdao, Shandong, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2019年 / 23卷 / 15期
关键词：
Long non-coding RNA; DLX6-AS1; Ovarian cancer; MiR-613; INHIBITS CELL-PROLIFERATION; APOPTOSIS; MIGRATION; KNOCKDOWN; EXPRESSION; INVASION;
D O I：
10.26355/eurrev_201908_18524
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: Recently, long non-coding RNAs (lncRNAs) have been extensively studied for their role in tumor progression. This work explored the role of lncRNA DLX6-AS1 in mediating the development of ovarian cancer (OC). PATIENTS AND METHODS: DLX6-AS1 expression was detected by Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) in OC tissues. Moreover, wound healing assay and transwell assay were performed to detect the effect of DLX6-AS1 on the metastasis of OC. Furthermore, the underlying mechanism of DLX6-AS1 in mediating the progression of OC was explored through the Dual-Luciferase reporter gene assay and RNA immunoprecipitation assay (RIP). RESULTS: DLX6-AS1 expression was higher in OC samples than that in the adjacent ones. Moreover, cell migration and invasion were suppressed after DLX6-AS1 knockdown in vitro. Conversely, cell migration and invasion were promoted by overexpressed DLX6-AS1. Moreover, the expression of microRNA-613 (miR-613) was upregulated via knockdown of DLX6-AS1, but was downregulated after overexpression of DLX6-AS1. Furthermore, the Luciferase reporter gene assay and RIP assay showed that miR-613 was a direct target of MIAT in DLX6-AS1 in OC tissues. CONCLUSIONS: DLX6-AS1 could enhance migration and invasion of OC cells via targeting miR-613, which might serve as a potential therapeutic target in OC.
引用
收藏
页码：6429 / 6435
页数：7
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