THE ROLE OF TAQI DRD2 (RS1800497) AND DRD4 VNTR POLYMORPHISMS IN POSTTRAUMATIC STRESS DISORDER (PTSD)

被引：11

作者：

Hoxha, Blerina ^{[1
]}

Uka, Aferdita Goci ^{[1
]}

Agani, Fetid ^{[2
]}

Haxhibeqiri, Shpend ^{[3
]}

Haxhibeqiri, Valdete ^{[4
]}

Dzananovic, EmMa Sabic ^{[5
]}

Kucukalic, Sabina ^{[5
]}

Mehmedbasic, Alma Bravo ^{[5
]}

Kucukalic, Abdulah ^{[5
]}

Kulenovic, Alma Dzubur ^{[5
]}

Bojic, Elma Feric ^{[6
]}

Marjanovic, Damir ^{[6
,7
]}

Kravic, Nermina ^{[8
]}

Avdibegovic, Esmina ^{[8
]}

Umihanic, Mirnesa Muminovic ^{[9
]}

Jaksic, Nenad ^{[10
]}

Franc, Ana Cima ^{[10
]}

Rudan, Dusko ^{[10
]}

Jakovljevic, Miro ^{[10
]}

Babic, Romana ^{[11
]}

Paylovic, Marko ^{[11
]}

Babic, Dragan ^{[11
]}

Margetic, Branka Aukst ^{[12
]}

Bozina, Nada ^{[13
]}

Sinanovic, Osman ^{[14
]}

Ziegler, Christiane ^{[15
]}

Warrings, Bodo ^{[16
]}

Domschke, Katharina ^{[15
]}

Deckert, Juergen ^{[16
]}

Wolf, Christiane ^{[17
]}

Vyshka, Gentian ^{[17
]}

机构：

[1] Univ Clin Ctr Kosovo, Dept Psychiat, Prishtina, Kosovo

[2] Univ Hasan Prishtina, Fac Med, Prishtina, Kosovo

[3] Univ Clin Ctr Kosovo, Inst Kosovo Forens Psychiat, Prishtina, Kosovo

[4] Univ Clin Ctr Kosovo, Dept Med Biochem, Prishtina, Kosovo

[5] Univ Clin Ctr, Dept Psychiat, Sarajevo, Bosnia & Herceg

[6] Int Burch Univ, Dept Genet & Bioengn, Sarajevo, Bosnia & Herceg

[7] Inst Anthropol Res, Zagreb, Croatia

[8] Univ Clin Ctr Tuzla, Dept Psychiat, Tuzla, Bosnia & Herceg

[9] Community Hlth Ctr Zivinice, Zivinice, Bosnia & Herceg

[10] Univ Hosp Ctr Zagreb, Dept Psychiat, Zagreb, Croatia

[11] Univ Clin Ctr Mostar, Dept Psychiat, Mostar, Bosnia & Herceg

[12] Univ Hosp Sestre Milosrdnice, Dept Psychiat, Zagreb, Croatia

[13] Univ Hosp Ctr Zagreb, Dept Lab Diagnost, Zagreb, Croatia

[14] Univ Clin Ctr Tuzla, Dept Neurol, Tuzla, Bosnia & Herceg

[15] Univ Freiburg, Dept Psychiat & Psychotherapy, Fac Med, Med Ctr, Freiburg, Germany

[16] Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany

[17] Univ Med Tirana, Fac Med, Biomed & Expt Dept, Tirana, Albania

来源：

PSYCHIATRIA DANUBINA | 2019年 / 31卷 / 02期

关键词：

PTSD; DRD2; rs; 1800497; variant; DRD4 VNTR Exon 3; CAPS; BSI; D2; DOPAMINE-RECEPTOR; PLASMA DOPAMINE; GENE; ASSOCIATION; VETERANS;

D O I：

10.24869/psyd.2019.263

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Posttraumatic stress disorder (PTSD) is a complex stress related disorder, that follows a severe traumatic experience, characterized with an intense sense of terror, fear, and helplessness. The aim of this study is to identify associations of genetic variations within candidate genes DRD2 and DRD4 with various PTSD related phenotypes. PTSD lifetime and PTSD current subjects were analyzed separately, each of them were analyzed in a Case/Control design, as well as regarding BSI and CAPS within cases only. Subjects and methods: 719 (487 male, 232 female) participants who had experienced war-related trauma between 1991 and 1999 in Bosnia and Hercegovina, Kosovo and Croatia were included in the study. Sociodemographic questionnaire, Clinician Administered PTSD Scale (CAPS) and the Brief Symptom Inventory (BSI) were used to collect clinical data. Results: The DRD2 rs1800497 variant and a variable number tandem repeat (VNTR) located in exon three of DRD4 were investigated for association with PTSD. In case control analyses we did not identify any significant associations. Within the PTSD current patients, we identified an association of DRD2 rs1800497 with BSI in the genotypic and the recessive model with the T allele as the risk allele. Conclusion: Our findings suggest that rs1800497 of DRD2 gene is involved in pathogenesis of PTSD.

引用

页码：263 / 268

页数：6

共 27 条

[1]

Aguirre-Samudio AJ, 2005, REV INVEST CLIN, V57, P65

[2]

[Anonymous], 2009, DEPRESSION ANXIETY, V26, P28

[3] The genetic background to PTSD [J].

Broekman, B. F. P. ;

Olff, M. ;

Boer, F. .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2007, 31 (03) :348-362

[4] Psychobiological and vulnerability : Implications for successful adaptation to extreme stress [J].

Charney, DS .

AMERICAN JOURNAL OF PSYCHIATRY, 2004, 161 (02) :195-216

[5]

Comings DE, 1996, AM J MED GENET, V67, P264, DOI 10.1002/(SICI)1096-8628(19960531)67:3<264::AID-AJMG4>3.0.CO

[6]

2-N

[7] Genetics of Post-Traumatic Stress Disorder: Review and Recommendations for Genome-Wide Association Studies [J].

Cornelis, Marilyn C. ;

Nugent, Nicole R. ;

Amstadter, Ananda B. ;

Koenen, Karestan C. .

CURRENT PSYCHIATRY REPORTS, 2010, 12 (04) :313-326

[8] Human genetics of plasma dopamine β-hydroxylase activity:: applications to research in psychiatry and neurology [J].

Cubells, JF ;

Zabetian, CP .

PSYCHOPHARMACOLOGY, 2004, 174 (04) :463-476

[9]

Deutch A. Y., 1990, PROG BRAIN RES, V85, P402

[10]

Deutch Ariel Y., 1995, P163

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