Therapeutic potential of Toll-like receptor 9 activation

被引：1034
作者：
Krieg, Arthur M. [1 ]
机构：
[1] Coley Pharmaceut Grp Inc, Wellesley, MA 02481 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 06期
关键词：
D O I：
10.1038/nrd2059
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
In the decade since the discovery that mouse B cells respond to certain unmethylated CpG dinucleotides in bacterial DNA, a specific receptor for these 'CpG motifs' has been identified, Toll-like receptor 9 (TLR9), and a new approach to immunotherapy has moved into the clinic based on the use of synthetic oligodeoxynucleotides (ODN) as TLR9 agonists. This review highlights the current understanding of the mechanism of action of these CpG ODN, and provides an overview of the preclinical data and early human clinical trial results using these drugs to improve vaccines and treat cancer, infectious disease and allergy/asthma.
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收藏
页码：471 / 484
页数：14
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