The United Nations has adopted a Convention on the Rights of Persons with Disabilities on 1 December 2006. Article 24 commits the signatory states to offer education without discrimination and based on equal opportunity for gaining self-realization and employment. Adequate education is still not accessible for all groups of disabled in our country, although the Slovak Republic became a signatory to the Convention by the president's signature on 26 September 2007. This fact was the impulse for addressing the topic of online education of the disabled. Development of Information Technologies in the 21st century opens new possibilities of educating disabled children and students. Rapid changes in the e-learning industry allow the use of various applications included directly in the environment of Learning Management Systems and online education brings new ways of perceiving, understanding, interacting and dealing with the information for all students. The main objective of the paper is to examine the needs of people with disabilities concerning IT in education and to select appropriate software tools and applications that can be implemented in the chosen Learning Management System. We have prepared pilot courses in LMS Moodle 3.6 that include some useful software applications (single source authentication, text-to-speech application, chat dialogue box, skype, etc.), which would simplify the education of people with multiple disabilities. The open concept of LMS Moodle offers plenty of features and new apps in stable versions, which are useful in overcoming educational barriers.