LncRNA SNHG6 acts as a prognostic factor to regulate cell proliferation in glioma through targeting p21

被引：41

作者：

Cai, Gang ^{[1
]}

Zhu, Qing ^{[1
]}

Yuan, Liqun ^{[1
]}

Lan, Qing ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 2, Dept Neurosurg, 1055 Sanxiang Rd, Suzhou 215004, Jiangsu, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 102卷

关键词：

SNHG6; Proliferation; Prognosis; Glioma; LONG NONCODING RNA; HEPATOCELLULAR-CARCINOMA; EXPRESSION; PROMOTES; OSTEOSARCOMA; PROGRESSION; TUG1;

D O I：

10.1016/j.biopha.2018.03.083

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It has been certified that long noncoding RNAs (lncRNAs) are crucial regulators in the progression of various human cancers. snoRNA host gene 6 (SNHG6) has been uncovered to affect the initial stage and tumorigenesis of hepatocellular carcinoma. Nevertheless, the expression pattern and biological role of SNHG6 in glioma still need to be investigated. The study aims to investigate the expression pattern, biological role and the potential mechanism of SNHG6 in glioma. In this study, the high expression of SNHG6 was tested in both glioma tissues and glioma cells. The correlation between expression levels of SNHG6 and the overall survival of glioma patients was demonstrated by using Kaplan Meier method analysis. Next, gain of function assays revealed that overexpression of SNHG6 can promote the formation of malignant phenotype of 1800 cell. However, results of loss-of-function assays revealed that silenced SNHG6 exerted the inhibitory function on glioma cell growth. Flow cytometric analysis was performed in glioma cells to detect the anti-oncogenic effects of silenced SNHG6 on cell cycle and apoptosis. Finally, we identified that p21 was involved in glioma cell proliferation after SNHG6 was down regulated. Taken together, we concluded that SNHG6 is a regulator and a potential therapeutic target in glioma.

引用

页码：452 / 457

页数：6

共 23 条

[1] The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma [J].

Cao, C. ;

Zhang, T. ;

Zhang, D. ;

Xie, L. ;

Zou, X. ;

Lei, L. ;

Wu, D. ;

Liu, L. .

ONCOGENE, 2017, 36 (08) :1112-1122

[2] Upregulation of SNHG6 regulates ZEB1 expression by competitively binding miR-101-3p and interacting with UPF1 in hepatocellular carcinoma [J].

Chang, Lei ;

Yuan, Yufeng ;

Li, Cuicui ;

Guo, Tao ;

Qi, Haolong ;

Xiao, Yusha ;

Dong, Xu ;

Liu, Zhisu ;

Liu, Quanyan .

CANCER LETTERS, 2016, 383 (02) :183-194

[3] EZH2-mediated α-actin methylation needs lncRNA TUG1, and promotes the cortex cytoskeleton formation in VSMCs [J].

Chen, Rong ;

Kong, Peng ;

Zhang, Fan ;

Shu, Ya-Nan ;

Nie, Xi ;

Dong, Li-Hua ;

Lin, Yan-Ling ;

Xie, Xiao-Li ;

Zhao, Li-Li ;

Zhang, Xiang-Jian ;

Han, Mei .

GENE, 2017, 616 :52-57

[4] Impact of Dietary Interventions on Noncoding RNA Networks and mRNAs Encoding Chromatin-Related Factors [J].

Green, Christopher D. ;

Huang, Yi ;

Dou, Xiaoyang ;

Yang, Liu ;

Liu, Yong ;

Han, Jing-Dong J. .

CELL REPORTS, 2017, 18 (12) :2957-2968

[5]

Shen C, 2017, J DRUG TARGET, P1

[6] Long non-coding RNA CRNDE promotes gallbladder carcinoma carcinogenesis and as a scaffold of DMBT1 and C-IAP1 complexes to activating PI3K-AKT pathway [J].

Shen, Sheng ;

Liu, Han ;

Wang, Yueqi ;

Wang, Jiwen ;

Ni, Xiaolin ;

Ai, Zhilong ;

Pan, Hongtao ;

Liu, Houbao ;

Shao, Yebo .

ONCOTARGET, 2016, 7 (45) :72833-72844

[7] Frequently asked questions in the medical management of high-grade glioma: a short guide with practical answers [J].

Stupp, R. ;

Hottinger, A. F. ;

van den Bent, M. J. ;

Dietrich, P. -Y. ;

Brandes, A. A. .

ANNALS OF ONCOLOGY, 2008, 19 :209-216

[8] Long noncoding RNA BLACAT1 indicates a poor prognosis of colorectal cancer and affects cell proliferation by epigenetically silencing of p15 [J].

Su, Jun ;

Zhang, Erbao ;

Han, Liang ;

Yin, Dandan ;

Liu, Zhili ;

He, Xuezhi ;

Zhang, Yuhong ;

Lin, Feng ;

Lin, Qingfeng ;

Mao, Peiyao ;

Mao, Weidong ;

Shen, Dong .

CELL DEATH & DISEASE, 2017, 8 :e2665-e2665

[9]

Sun C. C., 2016, NUCL ACIDS, V5, pe385

[10] MEG3 Long Noncoding RNA Contributes to the Epigenetic Regulation of Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines [J].

Terashima, Minoru ;

Tange, Shoichiro ;

Ishimura, Akihiko ;

Suzuki, Takeshi .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (01) :82-99

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