Peptide-based cancer therapy: Opportunity and challenge

被引：273

作者：

Wu, Dongdong ^{[1
]}

Gao, Yanfeng ^{[2
]}

Qi, Yuanming ^{[2
]}

Chen, Lixiang ^{[2
]}

Ma, Yuanfang ^{[1
]}

Li, Yanzhang ^{[1
]}

机构：

[1] Henan Univ, Coll Med, Kaifeng 475004, Henan, Peoples R China

[2] Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Henan, Peoples R China

来源：

CANCER LETTERS | 2014年 / 351卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Cancer therapy; Peptide; Anticancer mechanism; Modification strategy; ENDOTHELIAL GROWTH-FACTOR; PHAGE DISPLAY LIBRARY; HUMAN FIBROSARCOMA CELLS; EXHIBITS ANTITUMOR-ACTIVITY; TARGETED DRUG-DELIVERY; INHIBITS TUMOR-GROWTH; ANTIMICROBIAL PEPTIDE; BREAST-CANCER; ANTICANCER ACTIVITY; IN-VITRO;

D O I：

10.1016/j.canlet.2014.05.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is one of the leading causes of death worldwide. Conventional cancer therapies mainly focus on mass cell killing without high specificity and often cause severe side effects and toxicities. Peptides are a novel class of anticancer agents that could specifically target cancer cells with lower toxicity to normal tissues, which will offer new opportunities for cancer prevention and treatment. Anticancer peptides face several therapeutic challenges. In this review, we present the sources and mechanisms of anticancer peptides and further discuss modification strategies to improve the anticancer effects of bioactive peptides. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：13 / 22

页数：10

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