The ABCA subclass of mammalian transporters

被引：81

作者：

Broccardo, C ^{[1
]}

Luciani, MF ^{[1
]}

Chimini, G ^{[1
]}

机构：

[1] Ctr Immunol Marseille Luminy, F-13288 Marseille 09, France

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1999年 / 1461卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

ABCA subclass; ABC1; ABCR; consensus motif; gene family;

D O I：

10.1016/S0005-2736(99)00170-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe here a subclass of mammalian ABC transporters, the ABCA subfamily. This is a unique group that, in contrast to any other human ABC transporters, lacks a structural counterpart in yeast. The structural hallmark of the ABCA subfamily is the presence of a stretch of hydrophobic amino acids thought to span the membrane within the putative regulatory (R) domain. As for today, four ABCA transporters have been fully characterised but 11 ABCA-encoding genes have been identified. AECA-specific motifs in the nucleotide binding folds can be detected when analysing the conserved sequences among the different members. These motifs may reveal functional constraints exclusive to this group of ABC transporters. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：395 / 404

页数：10

共 45 条

[1] A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy (vol 15, pg 236, 1997) [J].

Allikmets, R .

NATURE GENETICS, 1997, 17 (01) :122-122

[2] Organization of the ABCR gene:: analysis of promoter and splice junction sequences [J].

Allikmets, R ;

Wasserman, WW ;

Hutchinson, A ;

Smallwood, P ;

Nathans, J ;

Rogan, PK ;

Schneider, TD ;

Dean, M .

GENE, 1998, 215 (01) :111-122

[3] Characterization of the human ABC superfamily: Isolation and mapping of 21 new genes using the expressed sequence tags database [J].

Allikmets, R ;

Gerrard, B ;

Hutchinson, A ;

Dean, M .

HUMAN MOLECULAR GENETICS, 1996, 5 (10) :1649-1655

[4] A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy [J].

Allikmets, R ;

Singh, N ;

Sun, H ;

Shroyer, NE ;

Hutchinson, A ;

Chidambaram, A ;

Gerrard, B ;

Baird, L ;

Stauffer, D ;

Peiffer, A ;

Rattner, A ;

Smallwood, P ;

Li, YX ;

Anderson, KL ;

Lewis, RA ;

Nathans, J ;

Leppert, M ;

Dean, M ;

Lupski, JR .

NATURE GENETICS, 1997, 15 (03) :236-246

[5] Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration [J].

Allikmets, R ;

Shroyer, NF ;

Singh, N ;

Seddon, JM ;

Lewis, RA ;

Bernstein, PS ;

Peiffer, A ;

Zabriskie, NA ;

Li, YX ;

Hutchinson, A ;

Dean, M ;

Lupski, JR ;

Leppert, M .

SCIENCE, 1997, 277 (5333) :1805-1807

[6] PARTIAL-PURIFICATION AND RECONSTITUTION OF THE HUMAN MULTIDRUG-RESISTANCE PUMP - CHARACTERIZATION OF THE DRUG-STIMULATABLE ATP HYDROLYSIS [J].

AMBUDKAR, SV ;

LELONG, IH ;

ZHANG, JP ;

CARDARELLI, CO ;

GOTTESMAN, MM ;

PASTAN, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) :8472-8476

[7] The human photoreceptor rim protein gene (ABCR):: genomic structure and primer set information for mutation analysis [J].

Azarian, SM ;

Megarity, CF ;

Weng, J ;

Horvath, DH ;

Travis, GH .

HUMAN GENETICS, 1998, 102 (06) :699-705

[8] The photoreceptor rim protein is an ABC transporter encoded by the gene for recessive Stargardt's disease (ABCR) [J].

Azarian, SM ;

Travis, GH .

FEBS LETTERS, 1997, 409 (02) :247-252

[9] The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease [J].

Bodzioch, M ;

Orsó, E ;

Klucken, T ;

Langmann, T ;

Böttcher, L ;

Diederich, W ;

Drobnik, W ;

Barlage, S ;

Büchler, C ;

Porsch-Özcürümez, M ;

Kaminski, WE ;

Hahmann, HW ;

Oette, K ;

Rothe, G ;

Aslanidis, C ;

Lackner, KJ ;

Schmitz, G .

NATURE GENETICS, 1999, 22 (04) :347-351

[10] Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency [J].

Brooks-Wilson, A ;

Marcil, M ;

Clee, SM ;

Zhang, LH ;

Roomp, K ;

van Dam, M ;

Yu, L ;

Brewer, C ;

Collins, JA ;

Molhuizen, HOF ;

Loubser, O ;

Ouelette, BFF ;

Fichter, K ;

Ashbourne-Excoffon, KJD ;

Sensen, CW ;

Scherer, S ;

Mott, S ;

Denis, M ;

Martindale, D ;

Frohlich, J ;

Morgan, K ;

Koop, B ;

Pimstone, S ;

Kastelein, JJP ;

Genest, J ;

Hayden, MR .

NATURE GENETICS, 1999, 22 (04) :336-345

← 1 2 3 4 5 →