Stemoninines from the roots of Stemona tuberosa

被引：70
作者：
Lin, Li-Gen
Zhong, Qiong-Xing
Cheng, Tin-Yan
Tang, Chun-Ping
Ke, Chang-Qiang
Lin, Ge
Ye, Yang
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
[2] Hainan Normal Univ, Dept Biol, Haikou 571158, Peoples R China
[3] Chinese Univ Hong Kong, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 07期
关键词：
D O I：
10.1021/np0505317
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Five new stemoninine-type alkaloids, bisdehydrostemoninine ( 1), isobisdehydrostemoninine ( 2), bisdehydroneostemoninine ( 3), and bisdehydrostemoninines A ( 4) and B ( 5), were isolated from the crude-alkaloid extract of the roots of Stemona tuberosa. Their structures were elucidated on the basis of one- and two-dimensional NMR and other spectroscopic studies. The relative configuration of 4 was determined by X-ray diffraction. Alkaloid 1 displayed significant antitussive activity in the citric acid-induced guinea pig cough model.
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页码：1051 / 1054
页数：4
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