Modeling-based determination of physiological parameters of systemic VOCs by breath gas analysis, part 2

被引：11

作者：

Ager, Clemens ^{[1
,2
]}

Unterkofler, Karl ^{[1
,3
]}

Mochalski, Pawel ^{[1
]}

Teschl, Susanne

Teschl, Gerald ^{[4
,5
]}

Mayhew, Chris A. ^{[1
]}

King, Julian ^{[1
]}

机构：

[1] Univ Innsbruck, Breath Res Inst, Rathauspl 4, A-6850 Dornbirn, Austria

[2] Innsbruck Med Univ, Univ Clin Anesthesia & Intens Care, Anichstr 35, A-6020 Innsbruck, Austria

[3] Univ Appl Sci Vorarlberg, Hsch Str 1, A-6850 Dornbirn, Austria

[4] Univ Appl Sci Tech Wien, Hsch Pl 6, A-1200 Vienna, Austria

[5] Univ Vienna, Fac Math, Oskar Morgenstern Pl 1, A-1090 Vienna, Austria

来源：

JOURNAL OF BREATH RESEARCH | 2018年 / 12卷 / 03期

基金：

奥地利科学基金会;

关键词：

modeling; breath gas analysis; volatile organic compounds (VOCs); metabolic rates; production rates; acetone; PARTITION-COEFFICIENTS; WATER; TEMPERATURE; COMPILATION; ELIMINATION; ETHANOL; AIRWAYS; BLOOD; AIR;

D O I：

10.1088/1752-7163/aab2b6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In a recent paper (Unterkofler et al 2015 J. Breath Res. 9 036002) we presented a simple two compartment model which describes the influence of inhaled concentrations on exhaled breath concentrations for volatile organic compounds (VOCs) with small Henry constants. In this paper we extend this investigation concerning the influence of inhaled concentrations on exhaled breath concentrations for VOCs with higher Henry constants. To this end we extend our model with an additional compartment which takes into account the influence of the upper airways on exhaled breath VOC concentrations.

引用

页数：9

共 17 条

[1] Modeling soluble gas exchange in the airways and alveoli
Anderson, JC
Babb, AL
Hlastala, MP
[J]. ANNALS OF BIOMEDICAL ENGINEERING, 2003, 31 (11) : 1402 - 1422
[2] Alcohol Metabolism
Cederbaum, Arthur I.
[J]. CLINICS IN LIVER DISEASE, 2012, 16 (04) : 667 - +
[3] ELIMINATION OF INERT GAS BY LUNG
FARHI, LE
[J]. RESPIRATION PHYSIOLOGY, 1967, 3 (01): : 1 - &
[4] REGIONAL CONTROL OF LOCAL AIRWAY HEAT AND WATER-VAPOR LOSSES
HANNA, LM
SCHERER, PW
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 1986, 61 (02) : 624 - 632
[5] EFFECTS OF TEMPERATURE AND HUMIDITY OF INHALED AIR ON THE CONCENTRATION OF ETHANOL IN A MANS EXHALED BREATH
JONES, AW
[J]. CLINICAL SCIENCE, 1982, 63 (05) : 441 - 445
[6] DETERMINATION OF LIQUID AIR PARTITION-COEFFICIENTS FOR DILUTE-SOLUTIONS OF ETHANOL IN WATER, WHOLE-BLOOD, AND PLASMA
JONES, AW
[J]. JOURNAL OF ANALYTICAL TOXICOLOGY, 1983, 7 (04) : 193 - 197
[7] A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone
King, Julian
Unterkofler, Karl
Teschl, Gerald
Teschl, Susanne
Koc, Helin
Hinterhuber, Hartmann
Amann, Anton
[J]. JOURNAL OF MATHEMATICAL BIOLOGY, 2011, 63 (05) : 959 - 999
[8] Lumb A., 2005, NUNNS APPL RESP PHYS, V6th
[9] THERMAL MAPPING OF THE AIRWAYS IN HUMANS
MCFADDEN, ER
PICHURKO, BM
BOWMAN, HF
INGENITO, E
BURNS, S
DOWLING, N
SOLWAY, J
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 1985, 58 (02) : 564 - 570
[10] AN ALGORITHM FOR PREDICTING TISSUE-BLOOD PARTITION-COEFFICIENTS OF ORGANIC-CHEMICALS FROM N-OCTANOL-WATER PARTITION-COEFFICIENT DATA
POULIN, P
KRISHNAN, K
[J]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1995, 46 (01): : 117 - 129

← 1 2 →