Everything you ever wanted to know about PKA regulation and its involvement in mammalian sperm capacitation

被引：37

作者：

Baro Graf, Carolina ^{[1
,2
]}

Ritagliati, Carla ^{[1
]}

Stival, Cintia ^{[1
]}

Luque, Guillermina M. ^{[3
]}

Gentile, Inaki ^{[1
]}

Buffone, Mariano G. ^{[3
]}

Krapf, Dario ^{[1
,2
]}

机构：

[1] CONICET UNR, Lab Cell Signal Transduct Networks, Inst Biol Mol & Celular Rosario IBR, Rosario, Argentina

[2] Univ Nacl Rosario, Fac Ciencias Bioquim & Farrnaceut, Lab Med Reprod LMR, Rosario, Argentina

[3] Consejo Nacl Invest Cient & Tecn, Lab Cellular & Mol Reprod Biol, Inst Biol & Med Expt IBYME, Buenos Aires, DF, Argentina

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2020年 / 518卷

关键词：

Protein kinase A (PKA); Sperm capacitation; Reproduction; cAMP; PROTEIN-KINASE-A; SOLUBLE ADENYLYL-CYCLASE; EPSILON-N-ACETYLLYSINE; BOVINE CARDIAC-MUSCLE; CATALYTIC SUBUNIT; MOUSE SPERM; TYROSINE PHOSPHORYLATION; ANCHORING PROTEIN; FIBROUS SHEATH; LYSINE ACETYLATION;

D O I：

10.1016/j.mce.2020.110992

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The 3', 5'-cyclic adenosine monophosphate (cAMP) dependent protein kinase (PKA) is a tetrameric holoenzyme comprising a set of two regulatory subunits (PKA-R) and two catalytic (PKA-C) subunits. The PKA-R subunits act as sensors of cAMP and allow PKA-C activity. One of the first signaling events observed during mammalian sperm capacitation is PKA activation. Thus, understanding how PKA activity is restricted in space and time is crucial to decipher the critical steps of sperm capacitation. It is widely accepted that PKA specificity depends on several levels of regulation. Anchoring proteins play a pivotal role in achieving proper localization signaling, subcellular targeting and cAMP microdomains. These multi-factorial regulation steps are necessary for a precise spatiotemporal activation of PKA. Here we discuss recent understanding of regulatory mechanisms of PKA in mammalian sperm, such as post-translational modifications, in the context of its role as the master orchestrator of molecular events conducive to capacitation.

引用

页数：18

共 275 条

[1] ADAMS JA, 1993, J BIOL CHEM, V268, P7747
[2] REGULATION OF HUMAN SPERM MOTILITY AND HYPERACTIVATION COMPONENTS BY CALCIUM, CALMODULIN, AND PROTEIN PHOSPHATASES
AHMAD, K
BRACHO, GE
WOLF, DP
TASH, JS
[J]. ARCHIVES OF ANDROLOGY, 1995, 35 (03): : 187 - 208
[3] AITKEN RJ, 1986, J REPROD FERTIL, V78, P515
[4] ACETYLATION + METHYLATION OF HISTONES + THEIR POSSIBLE ROLE IN REGULATION OF RNA SYNTHESIS
ALLFREY, VG
FAULKNER, R
MIRSKY, AE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1964, 51 (05) : 786 - +
[5] The tyrosine kinase FER is responsible for the capacitation-associated increase in tyrosine phosphorylation in murine sperm
Alvau, Antonio
Agustina Battistone, Maria
Gervasi, Maria Gracia
Navarrete, Felipe A.
Xu, Xinran
Sanchez-Cardenas, Claudia
Luis De la Vega-Beltran, Jose
Da Ros, Vanina G.
Greer, Peter A.
Darszon, Alberto
Krapf, Diego
Salicioni, Ana Maria
Cuasnicu, Patricia S.
Visconti, Pablo E.
[J]. DEVELOPMENT, 2016, 143 (13): : 2325 - 2333
[6] Compensatory regulation of RI alpha protein levels in protein kinase A mutant mice
Amieux, PS
Cummings, DE
Motamed, K
Brandon, EP
Wailes, LA
Le, K
Idzerda, RL
McKnight, GS
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (07) : 3993 - 3998
[7] Cyclic-AMP and pseudosubstrate effects on type-I A-kinase regulatory and catalytic subunit binding kinetics
Anand, Ganesh
Taylor, Susan S.
Johnson, David A.
[J]. BIOCHEMISTRY, 2007, 46 (32) : 9283 - 9291
[8] Molecular characterization of an anchor protein (AKAPCE) that binds the RI subunit (RCE) of type I protein kinase A from Caenorhabditis elegans
Angelo, R
Rubin, CS
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (23) : 14633 - 14643
[9] [Anonymous], 2016, NAT COMMUN, DOI DOI 10.1038/NCOMINS12963
[10] THE CAPACITATION OF THE MAMMALIAN SPERM
AUSTIN, CR
[J]. NATURE, 1952, 170 (4321) : 326 - 326

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