Coronary Artery Calcification Pathogenesis and Prognostic Implications

被引：385
作者：
Madhavan, Mahesh V. [1 ,2 ]
Tarigopula, Madhusudhan [3 ]
Mintz, Gary S. [3 ]
Maehara, Akiko [1 ,2 ,3 ]
Stone, Gregg W. [1 ,2 ,3 ]
Genereux, Philippe [1 ,2 ,3 ,4 ]
机构：
[1] New York Presbyterian Hosp, New York, NY USA
[2] Columbia Univ, Med Ctr, New York, NY 10022 USA
[3] Cardiovasc Res Fdn, New York, NY USA
[4] Univ Montreal, Hop Sacre Coeur Montreal, Montreal, PQ, Canada
来源：
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2014年 / 63卷 / 17期
关键词：
coronary artery calcification; coronary artery disease; PCI; ELUTING STENT IMPLANTATION; ULTRAFAST COMPUTED-TOMOGRAPHY; INTRAVASCULAR ULTRASOUND ANALYSIS; SPEED ROTATIONAL ATHERECTOMY; EXCIMER-LASER ANGIOPLASTY; GENOME-WIDE ASSOCIATION; ANGIOGRAPHIC FOLLOW-UP; VASCULAR CALCIFICATION; BALLOON ANGIOPLASTY; CALCIUM SCORE;
D O I：
10.1016/j.jacc.2014.01.017
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Coronary artery calcification (CAC) is a risk factor for adverse outcomes in the general population and in patients with coronary artery disease. The pathogenesis of CAC and bone formation share common pathways, and risk factors have been identified that contribute to the initiation and progression of CAC. Efforts to control CAC with medical therapy have not been successful. Event-free survival is also reduced in patients with coronary calcification after both percutaneous coronary intervention (PCI) and bypass graft surgery. Although drug-eluting stents and devices for plaque modification have modestly improved outcomes in calcified vessels, adverse event rates are still high. Innovative pharmacologic and device-based approaches are needed to improve the poor prognosis of patients with CAC. (C) 2014 by the American College of Cardiology Foundation
引用
收藏
页码：1703 / 1714
页数：12
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