Golden Bullet-Denosumab: Early Rapid Response of Metastatic Giant Cell Tumor of the Bone

被引：19

作者：

Demirsoy, Ugur ^{[1
]}

Karadogan, Meriban ^{[1
]}

Selek, Ozgur ^{[2
]}

Anik, Yonca ^{[3
]}

Aksu, Gorkem ^{[4
]}

Muezzinoglu, Bahar ^{[5
]}

Corapcioglu, Funda ^{[1
]}

机构：

[1] Kocaeli Univ, Dept Pediat Oncol, TR-41380 Umuttepe, Kocaeli, Turkey

[2] Kocaeli Univ, Dept Orthopaed & Traumatol, TR-41380 Umuttepe, Kocaeli, Turkey

[3] Kocaeli Univ, Dept Radiol, TR-41380 Umuttepe, Kocaeli, Turkey

[4] Kocaeli Univ, Dept Radiat Oncol, TR-41380 Umuttepe, Kocaeli, Turkey

[5] Kocaeli Univ, Dept Pathol, TR-41380 Umuttepe, Kocaeli, Turkey

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2014年 / 36卷 / 02期

关键词：

lung metastasis; denosumab; giant cell tumor of bone; CHILD;

D O I：

10.1097/MPH.0000000000000034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Giant cell tumor of the bone (GCTB) is usually a benign, locally aggressive tumor with metastatic potential. Histogenesis of GCTB is unknown and a correlation has not been found between histologic and clinical course. For this reason, many authors consider its prognosis unpredictable. Lung metastasis after GCTB treatment is well known and generally has unfavorable outcome, despite varied chemotherapy regimens. Denosumab, which inhibits RANK-RANKL interaction, is a new, promising actor among targeted therapeutic agents for GCTB. In this report, we emphasize on early rapid response to denosumab in metastatic GCTB.

引用

页码：156 / 158

页数：3

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