Macroscopic Type Is a Prognostic Factor for Recurrence-free Survival After Resection of Gastric GIST

被引：0

作者：

Miyamoto, Hiroshi ^{[1
]}

Kunisaki, Chikara ^{[3
]}

Otsuka, Yuichi ^{[4
]}

Takahashi, Masazumi ^{[5
]}

Takagawa, Ryo ^{[6
]}

Misuta, Koichiro ^{[7
]}

Kameda, Kunio ^{[5
]}

Makino, Hirochika ^{[1
]}

Matsuda, Goro ^{[8
]}

Yamaguchi, Naotaka ^{[9
]}

Kamiya, Noriyuki ^{[10
]}

Murakami, Takashi ^{[11
]}

Morita, Satoshi ^{[2
]}

Akiyama, Hirotoshi ^{[1
]}

Endo, Itaru ^{[1
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Surg Gastroenterol, Yokohama, Kanagawa 2360004, Japan

[2] Yokohama City Univ, Grad Sch Med, Dept Biostat & Epidemiol, Yokohama, Kanagawa 2360004, Japan

[3] Yokohama City Univ, Dept Surg, Gastroenterol Ctr, Yokohama, Kanagawa 2360004, Japan

[4] Kanto Med Ctr NTT EC, Dept Surg, Tokyo, Japan

[5] Yokohama City Univ, Dept Surg, Yokohama, Kanagawa 2360004, Japan

[6] Yokosuka Kyosai Hosp, Dept Surg, Yokosuka, Kanagawa, Japan

[7] Fujisawa City Hosp, Dept Surg, Fujisawa, Kanagawa, Japan

[8] Yokohama Med Ctr, Natl Hosp Org, Dept Surg, Yokohama, Kanagawa, Japan

[9] Yokohama City Minato Red Cross Hosp, Dept Surg, Yokohama, Kanagawa, Japan

[10] Ito Municipal Hosp, Dept Surg, Ito, Japan

[11] Yokohama Ekisaikai Hosp, Dept Surg, Yokohama, Kanagawa, Japan

来源：

ANTICANCER RESEARCH | 2014年 / 34卷 / 08期

关键词：

Gastrointestinal stromal tumor; GIST; prognosis; risk of recurrence; GASTROINTESTINAL STROMAL TUMORS; TERM-FOLLOW-UP; SURGICAL-TREATMENT; SMALL-INTESTINE; RISK; DIAGNOSIS; MALIGNANCY; MORPHOLOGY; PATHOLOGY; IMATINIB;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Accurate evaluation of the biological behavior of Gastrointestinal stromal tumor and careful selection of patients with a high risk for tumor recurrence are necessary. In the present study, we analyzed prognostic factors in patients with GIST. Patients and Methods: A total of 214 patients who had undergone curative resection of a localized primary gastric GIST without adjuvant therapy were enrolled in this retrospective study. Prognostic factors were analyzed. The growth pattern was classified as intramural, endoluminal, exoluminal, or mixed- type. Results: On univariate and multivariate analyses, recurrence was predicted by exoluminal or mixed-type (hazard ratio [HR]=3.7, p=0.043), tumor size of >3.5 cm (HR=7.1, p=0.01), and mitotic rate of >5/50 high-power fields (HR=7.9, p<0.001). Conclusion: It is suggested that exoluminal or mixed-type is independently associated with recurrence of surgically resected gastric GIST in addition to tumor size and mitotic rate.

引用

页码：4267 / 4273

页数：7

共 31 条

[1] Agaimy A, 2012, INT J CLIN EXP PATHO, V5, P12
[2] Agaimy A, 2010, INT J CLIN EXP PATHO, V3, P461
[3] Population-based study of the diagnosis and treatment of gastrointestinal stromal tumours
Bumming, P.
Ahlman, H.
Andersson, J.
Meis-Kindblom, J. M.
Kindblom, L. -G.
Nilsson, B.
[J]. BRITISH JOURNAL OF SURGERY, 2006, 93 (07) : 836 - 843
[4] Prognostic analysis of patients with gastrointestinal stromal tumors: a single unit experience with surgical treatment of primary disease
Cao Hui
Zhang Yun
Wang Ming
Shen Dan-ping
Sheng Zhi-yong
Ni Xing-zhi
Wu Zhi-yong
Liu Qiang
Shen Yan-ying
Song Yan-yan
[J]. CHINESE MEDICAL JOURNAL, 2010, 123 (02) : 131 - 136
[5] Malignant Gastrointestinal Stromal Tumors of the Small Intestine: A Review of 50 Cases From a Prospective Database
Jacqueline A. Crosby
Charles N. Catton
Aileen Davis
Jean Couture
Brian O’Sullivan
Rita Kandel
Carol J. Swallow
[J]. Annals of Surgical Oncology, 2001, 8 (1) : 50 - 59
[6] Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST)
DeMatteo, Ronald P.
Gold, Jason S.
Saran, Lisa
Goenen, Mithat
Liau, Kui Hin
Maki, Robert G.
Singer, Samuel
Besmer, Peter
Brennan, Murray F.
Antonescu, Cristina R.
[J]. CANCER, 2008, 112 (03) : 608 - 615
[7] Two hundred gastrointestinal stromal tumors - Recurrence patterns and prognostic factors for survival
DeMatteo, RP
Lewis, JJ
Leung, D
Mudan, SS
Woodruff, JM
Brennan, MF
[J]. ANNALS OF SURGERY, 2000, 231 (01) : 51 - 58
[8] Prognosis of gastrointestinal smooth-muscle (Stromal) tumors - Dependence on anatomic site
Emory, TS
Sobin, LH
Lukes, L
Lee, DH
O'Leary, TJ
[J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1999, 23 (01) : 82 - 87
[9] Diagnosis of gastrointestinal stromal tumors: A consensus approach
Fletcher, CDM
Berman, JJ
Corless, C
Gorstein, F
Lasota, J
Longley, BJ
Miettinen, M
O'Leary, TJ
Remotti, H
Rubin, BP
Shmookler, B
Sobin, LH
Weiss, SW
[J]. HUMAN PATHOLOGY, 2002, 33 (05) : 459 - 465
[10] Clinicopathologic study of primary malignant gastrointestinal stromal tumor of the stomach, with special reference to prognostic factors: Analysis of results in 140 surgically resected patients
Yoshiya Fujimoto
Yukihiro Nakanishi
Kimio Yoshimura
Tadakazu Shimoda
[J]. Gastric Cancer, 2003, 6 (1) : 39 - 48

← 1 2 3 4 →