Effect of opioid and cannabinoid receptor antagonism on orphanin FQ-induced hyperphagia in rats

被引：19

作者：

Pietras, TA ^{[1
]}

Rowland, NE ^{[1
]}

机构：

[1] Univ Florida, Dept Psychol, Gainesville, FL 32611 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2002年 / 442卷 / 03期

关键词：

orphanin FQ; endocannabinoid; SR; 141716; naloxone; opioid; hyperphagia; anorexia; drug additivity;

D O I：

10.1016/S0014-2999(02)01551-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Feeding induced in rats by cerebroventricular (i.c.v.) injection of orphanin FQ was potently and dose-dependently reversed by peripheral injection of either the opioid antagonist naloxone or the cannabinoid CB1 receptor antagonist SR 141716{N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophelyl)-4-methyl-3-pyrazole-carboxamine}. The combination of these two agents inhibited food intake in a manner suggestive of additivity or supra-additivity. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：237 / 239

页数：3

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