Effect of opioid and cannabinoid receptor antagonism on orphanin FQ-induced hyperphagia in rats

被引：19
作者：
Pietras, TA [1 ]
Rowland, NE [1 ]
机构：
[1] Univ Florida, Dept Psychol, Gainesville, FL 32611 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2002年 / 442卷 / 03期
关键词：
orphanin FQ; endocannabinoid; SR; 141716; naloxone; opioid; hyperphagia; anorexia; drug additivity;
D O I：
10.1016/S0014-2999(02)01551-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Feeding induced in rats by cerebroventricular (i.c.v.) injection of orphanin FQ was potently and dose-dependently reversed by peripheral injection of either the opioid antagonist naloxone or the cannabinoid CB1 receptor antagonist SR 141716{N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophelyl)-4-methyl-3-pyrazole-carboxamine}. The combination of these two agents inhibited food intake in a manner suggestive of additivity or supra-additivity. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：237 / 239
页数：3
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