Effect of opioid and cannabinoid receptor antagonism on orphanin FQ-induced hyperphagia in rats

被引：19
作者：
Pietras, TA [1 ]
Rowland, NE [1 ]
机构：
[1] Univ Florida, Dept Psychol, Gainesville, FL 32611 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2002年 / 442卷 / 03期
关键词：
orphanin FQ; endocannabinoid; SR; 141716; naloxone; opioid; hyperphagia; anorexia; drug additivity;
D O I：
10.1016/S0014-2999(02)01551-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Feeding induced in rats by cerebroventricular (i.c.v.) injection of orphanin FQ was potently and dose-dependently reversed by peripheral injection of either the opioid antagonist naloxone or the cannabinoid CB1 receptor antagonist SR 141716{N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophelyl)-4-methyl-3-pyrazole-carboxamine}. The combination of these two agents inhibited food intake in a manner suggestive of additivity or supra-additivity. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：237 / 239
页数：3
相关论文
共 50 条
  • [1] Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia
    Leventhal, L
    Mathis, JP
    Rossi, GC
    Pasternak, GW
    Bodnar, RJ
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 349 (01) : R1 - R3
  • [2] Naloxone sensitive orphanin FQ-induced analgesia in mice
    Rossi, GC
    Leventhal, L
    Pasternak, GW
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 311 (2-3) : R7 - R8
  • [3] Nociceptin/Orphanin FQ Receptor Activation Attenuates Antinociception Induced by Mixed Nociceptin/Orphanin FQ/μ-Opioid Receptor Agonists
    Khroyan, Taline V.
    Polgar, Willma E.
    Jiang, Faming
    Zaveri, Nurulain T.
    Toll, Lawrence
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2009, 331 (03) : 946 - 953
  • [4] Acetyl-RYYRIK-NH2, a purported orphanin FQ antagonist, does not block the orphanin FQ-induced prolactin secretory response in female rats
    Janik, J
    Krupica, T
    Dengler, L
    Murphree, E
    Callahan, P
    NEUROSCIENCE LETTERS, 2003, 345 (03) : 149 - 152
  • [5] Antagonistic effect of orphanin FQ on opioid analgesia in rat
    Zhu, CB
    Zhang, XL
    Xu, SF
    Cao, XD
    Wu, GC
    Li, MY
    Cui, DF
    Qi, ZW
    ACTA PHARMACOLOGICA SINICA, 1998, 19 (01) : 10 - 14
  • [6] The hyperphagic effect of nociceptin/orphanin FQ in rats.
    Polidori, C
    de Caro, G
    Massi, M
    PEPTIDES, 2000, 21 (07) : 1051 - 1062
  • [7] Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ
    Mogil, JS
    Grisel, JE
    Zhangs, G
    Belknap, JK
    Grandy, DK
    NEUROSCIENCE LETTERS, 1996, 214 (2-3) : 131 - 134
  • [8] Stimulation of δ Opioid Receptor and Blockade of Nociceptin/Orphanin FQ Receptor Synergistically Attenuate Parkinsonism
    Mabrouk, Omar S.
    Viaro, Riccardo
    Volta, Mattia
    Ledonne, Ada
    Mercuri, Nicola
    Morari, Michele
    JOURNAL OF NEUROSCIENCE, 2014, 34 (39) : 12953 - 12962
  • [9] Nociceptin/orphanin FQ opioid peptide-receptor expression in pachyonychia congenita
    Pan, Baohan
    Schroeder, Wolfgang
    Jostock, Ruth
    Schwartz, Mary
    Rosson, Gedge
    Polydefkis, Michael
    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2018, 23 (04) : 241 - 248
  • [10] Assessment of nociceptin/orphanin FQ and μ-opioid receptor mRNA in the human right atrium
    McDonald, J.
    Leonard, A. D.
    Serrano-Gomez, A.
    Young, S. P.
    Swanevelder, J.
    Thompson, J. P.
    Lambert, D. G.
    BRITISH JOURNAL OF ANAESTHESIA, 2010, 104 (06) : 698 - 704
12345