Immunohistochemical expression of MMP-7 protein and its serum level in colorectal cancer

被引：12

作者：

Pryczynicz, Anna ^{[1
]}

Gryko, Mariusz ^{[2
]}

Niewiarowska, Katarzyna ^{[1
]}

Dymicka-Piekarska, Violetta ^{[3
]}

Ustymowicz, Marek ^{[4
]}

Hawryluk, Maciej ^{[1
]}

Cepowicz, Dariusz ^{[2
]}

Borsuk, Agnieszka ^{[1
]}

Kemona, Andrzej ^{[1
]}

Famulski, Waldemar ^{[5
]}

Guzinska-Ustymowicz, Katarzyna ^{[1
]}

机构：

[1] Med Univ Bialystok, Dept Gen Pathomorphol, PL-15269 Bialystok, Poland

[2] Med Univ Bialystok, Dept Gen & Gastroenterol Surg 2, PL-15269 Bialystok, Poland

[3] Med Univ Bialystok, Dept Clin Lab Diagnost, PL-15269 Bialystok, Poland

[4] Bialystok Tech Univ, Fac Comp Sci, Bialystok, Poland

[5] Med Univ Bialystok, Dept Med Pathomorphol, PL-15269 Bialystok, Poland

来源：

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA | 2013年 / 51卷 / 03期

关键词：

colorectal cancer; matrix metalloproteinase-7; metastasis; serum level; colon; rectum; MATRIX METALLOPROTEINASE-7; MATRILYSIN MMP-7; COLON CARCINOMAS; E-CADHERIN; CLEAVAGE; CELLS; MATRIX-METALLOPROTEINASE-7; INVASION; TUMOR; OVEREXPRESSION;

D O I：

10.5603/FHC.2013.0029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The study objective was to determine the presence of MMP-7 in cancer tissue in correlation with its serum level in patients diagnosed with colorectal cancer (CRC). In 45 patients with CRC, MMP-7 expression was assessed immunohistochemically on FFPE slides in tumours (N = 37) and in the corresponding surgical margin sample. MMP-7 serum level was measured preoperatively. The expression of MMP-7 in cancer tissue was much stronger as compared to the normal intestinal mucosa. Also the level of MMP-7 in the serum of CRC patients was higher than in healthy subjects (N = 24) (p < 0.01). The tumour located in the colon showed higher expression of MMP-7 than CRCs located in the rectum (p < 0.05), whereas the higher MMP-7 serum level showed correlation with older age (p = 0.005), tumour size less than 5 cm (p < 0.05), higher Dukes' stage (p < 0.05) and distant metastases (p < 0.05). The increased serum level of MMP-7 in CRC patients may indicate the presence of distant metastases.

引用

页码：206 / 212

页数：7

共 38 条

[11] Matrix metalloproteinases in tumorigenesis: an evolving paradigm [J].