A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle

被引：150

作者：

Kim, Kyoung Sub ^{[1
]}

Park, Wooram ^{[1
]}

Hu, Jun ^{[2
]}

Bae, You Han ^{[2
]}

Na, Kun ^{[1
]}

机构：

[1] Catholic Univ Korea, Dept Biotechnol, Bucheon Si 420743, Gyeonggi Do, South Korea

[2] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USA

来源：

BIOMATERIALS | 2014年 / 35卷 / 01期

关键词：

Cancer diagnosis; Magnetic resonance imaging; Micelles; Imaging agents; pH-responsive materials; LIVER-CANCER; NANOPARTICLES; COPOLYMER; THERAPY; RELEASE; PROBE;

D O I：

10.1016/j.biomaterials.2013.10.004

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A cancer-recognizable MRI contrast agents (CR-CAs) has been developed using pH-responsive polymeric micelles. The CR-CAs with pH sensitivity were self-assembled based on well-defined amphiphilic block copolymers, consisting of methoxy poly(ethylene glycol)-b-poly(L-histidine) (PEG-p(L-His)) and methoxy poly(ethylene glycol)-b-poly(L-lactic acid)-diethylenetriaminopentaacetic acid dianhydride-gadolinium chelate (PEG-p(L-LA)-DTPA-Gd). The CR-CAs have a spherical shape with a uniform size of similar to 40 nm at physiological pH (pH 7.4). However, in acidic tumoral environment (pH 6.5), the CR-CAs were destabilized due to the protonation of the imidazole groups of p(L-His) blocks, causing them to break apart into positively charged water-soluble polymers. As a result, the CR-CAs exhibit highly effective T-1 MR contrast enhancement in the tumor region, which enabled the detection of small tumors of similar to 3 mm(3) in vivo at 1.5 T within a few minutes. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：337 / 343

页数：7

共 39 条

[1] Gd(III)-based contrast agents for MRI [J].