SIRT1 promotes the proliferation and metastasis of human pancreatic cancer cells

被引：28

作者：

Jin, Jianguang ^{[1
]}

Chu, Zhijie ^{[1
]}

Ma, Pengfei ^{[1
]}

Meng, Yuanpu ^{[1
]}

Yang, Yanhui ^{[1
]}

机构：

[1] Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Gen Surg, Luoyang 471003, Peoples R China

来源：

TUMOR BIOLOGY | 2017年 / 39卷 / 03期

关键词：

SIRT1; pancreatic carcinoma; proliferation; migration; TO-MESENCHYMAL TRANSITION; DEACETYLASE; SIRTUINS; METABOLISM; REGULATORS;

D O I：

10.1177/1010428317691180

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

SIRT1 plays an important role in human malignant progression, inducing cancer cell proliferation and metastasis by regulating downstream gene expressions. However, little is known about the underlying mechanisms in which SIRT1 promotes pancreatic cancer tumorigenesis. The aim of this study is to investigate the SIRT1 expression levels and biological functions in promoting pancreatic cancer progression. We first investigated the expression of SIRT1 in a series of pancreatic cancer tissues as well as in a panel of pancreatic cancer cell lines. The effect of SIRT1 on cell activity was explored by knockdown experiments. Cell growth was measured using the MTT assay and colony-formation assay. Migration and invasion were tested using transwell assay. Our results showed that the expression of SIRT1 was significantly up-regulated both in pancreatic cancer tissues and cell lines. Knockdown of SIRT1 suppressed cell proliferation and migration of pancreatic cancer cells. This is the first report to disclose the role of SIRT1 in regulation of pancreatic cancer cell proliferation and migration, which may provide a potential therapeutic target for pancreatic cancer patients.

引用

页数：6

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