New procedure for the preparation of the tetrazole analogue of GABA.

被引：7

作者：

Rival, Y ^{[1
]}

Wermuth, CG ^{[1
]}

机构：

[1] Univ Strasbourg 1, Lab Pharmacochim & Commun Cellulaire, CNRS, ERS 655, F-67401 Illkirch Graffenstaden, France

来源：

SYNTHETIC COMMUNICATIONS | 2000年 / 30卷 / 09期

关键词：

D O I：

10.1080/00397910008087193

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The hydrochloride of the tetrazolyl bioisostere of the neurotransmitter GABA can be easily prepared by means of three simple steps : a Gabriel-type substitution on 4-bromobutyronitrile with Boc(2)NH, a tetrazole formation by action of azidotributyltin on the cyano group and a deprotection step using gaseous HCl.

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页码：1587 / 1591

页数：5

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