Molecular Biomarkers for Celiac Disease: Past, Present and Future

被引：23

作者：

Ramirez-Sanchez, Aaron D. ^{[1
]}

Tan, Ineke L. ^{[1
,2
]}

Gonera-de Jong, B. C. ^{[3
]}

Visschedijk, Marijn C. ^{[2
]}

Jonkers, Iris ^{[1
]}

Withoff, Sebo ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Gastroenterol & Hepatol, NL-9700 RB Groningen, Netherlands

[3] Wilhelmina Hosp Assen, Dept Pediat, NL-9401 RK Assen, Netherlands

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 22期

关键词：

celiac disease; new biomarkers; diagnosis; follow-up; non-invasive; GLUTEN-FREE DIET; T-CELL RESPONSE; INTESTINAL PERMEABILITY; LARAZOTIDE ACETATE; GLIADIN PEPTIDES; MUCOSAL RECOVERY; ZONULIN LEVELS; RNA-SEQ; TRANSGLUTAMINASE; EXPRESSION;

D O I：

10.3390/ijms21228528

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Celiac disease (CeD) is a complex immune-mediated disorder that is triggered by dietary gluten in genetically predisposed individuals. CeD is characterized by inflammation and villous atrophy of the small intestine, which can lead to gastrointestinal complaints, malnutrition, and malignancies. Currently, diagnosis of CeD relies on serology (antibodies against transglutaminase and endomysium) and small-intestinal biopsies. Since small-intestinal biopsies require invasive upper-endoscopy, and serology cannot predict CeD in an early stage or be used for monitoring disease after initiation of a gluten-free diet, the search for non-invasive biomarkers is ongoing. Here, we summarize current and up-and-coming non-invasive biomarkers that may be able to predict, diagnose, and monitor the progression of CeD. We further discuss how current and emerging techniques, such as (single-cell) transcriptomics and genomics, can be used to uncover the pathophysiology of CeD and identify non-invasive biomarkers.

引用

页码：1 / 23

页数：25

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