Molecular Mechanisms of Glial Cells Related Signaling Pathways Involved in the Neuroinflammatory Response of Depression

被引：9

作者：

Wang, Junhui ^{[1
]}

Qin, Jie ^{[2
]}

Wang, Peng ^{[3
]}

Sun, Yu ^{[4
]}

Zhang, Qi ^{[5
]}

机构：

[1] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

[2] Qingdao Municipal Hosp, Dept Ultrasound, Qingdao, Shandong, Peoples R China

[3] Qingdao Univ, Sch Basic Med, Med Ctr, Qingdao, Shandong, Peoples R China

[4] Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan, Shandong, Peoples R China

[5] Western Univ, Schulich Sch Med & Dent, Dept Pathol & Lab Med, London, ON, Canada

来源：

MEDIATORS OF INFLAMMATION | 2020年 / 2020卷

关键词：

FUNCTIONAL GAP-JUNCTIONS; NICOTINIC ACETYLCHOLINE-RECEPTOR; NECROSIS-FACTOR-ALPHA; NLRP3; INFLAMMASOME; PREFRONTAL CORTEX; ACTIVATED MICROGLIA; HUMAN ASTROCYTES; QUINOLINIC ACID; EXPRESSION; INHIBITION;

D O I：

10.1155/2020/3497920

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dysfunction of the glial cells, such as astrocytes and microglia, is one of the pathological features in many psychiatric disorders, including depression, which emphasizes that glial cells driving neuroinflammation is not only an important pathological change in depression but also a potential therapeutic target. In this review, we summarized a recent update about several signaling pathways in which glial cells may play their roles in depression through neuroinflammatory reactions. We focused on the basic knowledge of these signaling pathways by elaborating each of them. This review may provide an updated image about the recent advances on these signaling pathways that are essential parts of neuroinflammation involved in depression.

引用

页数：9

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