G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population

被引:31
作者
Duffey, Lisa
Naumovski, Nenad
Ng, Xiaowei
Blades, Barbara
Yates, Zoe
Travers, Cheryl
Lewis, Peter
Sturm, Jonathon
Veysey, Martin
Roach, Paul D.
Lucock, Mark D.
机构
[1] Univ Newcastle, Sch Environm & Life Sci, Ourimbah, NSW 2258, Australia
[2] No Sydney Cent Coast Hlth, Teaching & Res Unit, Gosford, NSW 2250, Australia
[3] No Sydney Cent Coast Hlth, Publ Hlth Unit, Gosford, NSW 2250, Australia
关键词
folate; homocysteine; polymorphism; reduced folate carrier; hypertension; blood pressure;
D O I
10.1016/j.lfs.2006.05.009
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The functional consequences of the G80A RFC SNP on the expressed reduced folate carrier protein were evaluated by looking at the relationship between intake of folate, plasma folate and cellular stores of the vitamin. The effect on homocysteine was also examined. Homocysteine is a thiol that is known to be inversely associated with folate, and which is considered to be both tbrombo- and athrogenic. At high levels, homocysteine may also interfere with nitric oxide mediated vasodilation, cause oxidative injury to, and proliferation of the vascular endothelium, and alter the elastic properties of the vascular wall, contributing to increased blood pressure. Participants (119; 52 male, 67 female) from a NSW retirement village were assessed. Independent of gender, the assimilation of folate from dietary sources into red cells showed a significant association for GG (r=0399; p=0.022) and GA (r=0.564; p < 0.0001) subjects, but not homozygous recessive (AA) individuals r=0.223; p=0.236). The same genotype based pattern of significance was shown for the association between dietary folate and plasma folate (GG: r=0.524; p=0.002, GA: r=0.408; p=0.002). No genotype-related pattern of significance was shown for the association between dietary folate and homocysteine. When examined by gender, some differences were apparent; one-way ANOVA showed that genotype influenced diastolic blood pressure in males (v=0.019), while only females showed a significant correlation between dietary folate and blood pressure within specific genotypes (Systolic pressure GA: r=-0.372; p=0.025, carriage of A: r=O.-O.357; p=0.011. Diastolic pressure GA: r=-0.355; p=0.034.. carriage of A: r=0-0310;p-0.029). The G80A RFC SNP had an impact on the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:957 / 966
页数:10
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