Comparison of intraocular treatment of DMTU and SOD following retinal ischemia in rats

被引：9
作者：
Rios, L [1 ]
Cluzel, J [1 ]
Vennat, JC [1 ]
Menerath, JM [1 ]
Doly, M [1 ]
机构：
[1] Univ Auvergne, Fac Pharm, Lab Biophys Sensorielle, F-63001 Clermont Ferrand, France
来源：
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS | 1999年 / 15卷 / 06期
关键词：
D O I：
10.1089/jop.1999.15.547
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The effect of intravitreal injections of DMTU (dimethylthiourea) and SOD (superoxide dismutase), two free radical scavengers, was evaluated in a rat model of retinal ischemia induced by elevated intraocular pressure. The drugs were administered just before or just after a 60 min ischemia. At days 2 and 7 after reperfusion, retinal recovery was evaluated by electroretinography. At day 7, layer thicknesses and cell rows were measured from histologic sections of paraffin-embedded retinas. In the vehicle-treated control group, we observed a decrease in the inner retinal layers and b-wave amplitude impairment. SOD injection (6 units/eye) protected the retina from ischemia/reperfusion injury. At day 2 after reperfusion, electroretinographic recovery was more efficient when SOD was administered just after ischemia (99%) than after pretreatment with SOD (81%) (p<0.03). In the DMTU-treated group (75 mu g/eye), only the pretreatment induced significant electrophysiologic (40%) (p<0.001) and morphologic recovery.
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页码：547 / 556
页数：10
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