Long-term Use of β-Carotene, Retinol, Lycopene, and Lutein Supplements and Lung Cancer Risk: Results From the VITamins And Lifestyle (VITAL) Study

被引:95
作者
Satia, Jessie A. [1 ,2 ,3 ,4 ]
Littman, Alyson [5 ,6 ]
Slatore, Christopher G. [7 ]
Galanko, Joseph A. [4 ]
White, Emily [5 ,8 ]
机构
[1] Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Div Digest Dis & Nutr, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27599 USA
[5] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[6] VA Puget Sound Hlth Care Syst, Epidemiol Res & Informat Ctr, Seattle, WA USA
[7] Univ Washington, Div Pulm & Crit Care Med, Seattle, WA 98195 USA
[8] Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA 98104 USA
关键词
beta carotene; carotenoids; cohort studies; dietary supplements; lung neoplasms; randomized controlled trials as topic; vitamins; DIETARY CAROTENOIDS; WOMENS HEALTH; CARDIOVASCULAR-DISEASE; ALPHA-TOCOPHEROL; POOLED ANALYSIS; UNITED-STATES; COHORT; CONSUMPTION; NUTRITION; FRUIT;
D O I
10.1093/aje/kwn409
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
High-dose beta-carotene supplementation in high-risk persons has been linked to increased lung cancer risk in clinical trials; whether effects are similar in the general population is unclear. The authors examined associations of supplemental beta-carotene, retinol, vitamin A, lutein, and lycopene with lung cancer risk among participants, aged 50-76 years, in the VITamins And Lifestyle (VITAL) cohort Study in Washington State. In 2000-2002, eligible persons (n = 77,126) completed a 24-page baseline questionnaire, including detailed questions about supplement use (duration, frequency, dose) during the previous 10 years from multivitamins and individual supplements/mixtures. Incident lung cancers (n = 521) through December 2005 were identified by linkage to the Surveillance, Epidemiology, and End Results cancer registry. Longer duration of use of individual beta-carotene, retinol, and lutein supplements (but not total 10-year average dose) was associated with statistically significantly elevated risk of total lung cancer and histologic cell types; for example, hazard ratio = 2.02, 95% confidence interval: 1.28, 3.17 for individual supplemental lutein with total lung cancer and hazard ratio = 3.22, 95% confidence interval: 1.29, 8.07 for individual beta-carotene with small-cell lung cancer for > 4 years versus no use. There was little evidence for effect modification by gender or smoking status. Long-term use of individual beta-carotene, retinol, and lutein supplements should not be recommended for lung cancer prevention, particularly among smokers.
引用
收藏
页码:815 / 828
页数:14
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