Immune Cell Repertoire and Their Mediators in Patients with Acute Myocardial Infarction or Stable Angina Pectoris

被引:20
作者
Yan, Wenwen [1 ]
Song, Yanli [2 ]
Zhou, Lin [1 ]
Jiang, Jinfa [1 ]
Yang, Fang [3 ]
Duan, Qianglin [1 ]
Che, Lin [1 ]
Shen, Yuqin [1 ]
Song, Haoming [1 ]
Wang, Lemin [1 ]
机构
[1] Tongji Univ, Tongji Hosp, Sch Med, Dept Cardiol, 389 Xincun Rd, Shanghai 200065, Peoples R China
[2] Tongji Univ, Tongji Hosp, Sch Med, Dept Emergency Med, Shanghai 200065, Peoples R China
[3] Tongji Univ, Tongji Hosp, Sch Med, Dept Expt Diag, Shanghai 200065, Peoples R China
关键词
myocardial infarction; stable angina pectoris; gene expression; innate immunity; adaptive immunity; NATURAL-KILLER-CELLS; T-CELLS; SURFACE-IMMUNOGLOBULIN; NK CELLS; ATHEROSCLEROSIS; INFECTION; EXPRESSION; RECEPTORS; PATHOPHYSIOLOGY; INFLAMMATION;
D O I
10.7150/ijms.17119
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: To evaluate the natural innate and adaptive immunity through gene expression and cytology levels in peripheral blood mononuclear cells in patients with acute myocardial infarction (AMI), stable angina pectoris (SAP) and controls. Methods: 210 patients with AMI, 210 with SAP, and 250 clinical controls were recruited. Whole human genome microarray analysis was performed in 20 randomly chosen subjects per group were examined to detect the expressions of complement markers, natural killer cells, T cells and B cells. The quantity of these cells and related cytokines as well as immunoglobulin levels were measured in all subjects. Results: In AMI group, the mRNA expressions of late complement component, markers of natural killer cells, CD3+, CD8+ T cells and B cells were down-regulated, while those of early complement component and CD4+ T cells were up-regulated (p<0.05). In both AMI and SAP patients, the quantity of natural killer cells, CD3+, CD8+ T cells, B cells, IgM and IgG were significantly lower than those of the controls. CD4+ T cells, CH50, C3, C4, IL-2, IL-4, IL-6 and IFN-gamma were significantly higher (p<0.05). Conclusions: In AMI patients, both of gene expressions related to complement, natural killer cells, CD3+, CD8+ T cells, B cells and the quantity of these immune cells decreased while cell number reduced in SAP patients. Immune function in both AMI and SAP patients decreased especially in AMI patients with declined gene and protein levels. To improve the immune system is a potential target for medical interventions and prevention in AMI.
引用
收藏
页码:181 / 190
页数:10
相关论文
共 50 条
[1]   Acute Coronary Events [J].
Arbab-Zadeh, Armin ;
Nakano, Masataka ;
Virmani, Renu ;
Fuster, Valentin .
CIRCULATION, 2012, 125 (09) :1147-1156
[2]   Activation of natural killer cells:: Underlying molecular mechanisms revealed [J].
Backström, E ;
Kristensson, K ;
Ljunggren, HG .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2004, 60 (1-2) :14-22
[3]   Natural killer (NK) cell deficit in coronary artery disease: no aberrations in phenotype but sustained reduction of NK cells is associated with low-grade inflammation [J].
Backteman, K. ;
Ernerudh, J. ;
Jonasson, L. .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2014, 175 (01) :104-112
[4]   Uncoupling CD21 and CD19 of the B-cell coreceptor [J].
Barrington, Robert A. ;
Schneider, Thomas J. ;
Pitcher, Lisa A. ;
Mempel, Thorsten R. ;
Ma, Minghe ;
Barteneva, Natasha S. ;
Carroll, Michael C. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (34) :14490-14495
[5]   B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A [J].
Bergmann, Hannes ;
Yabas, Mehmet ;
Short, Alanna ;
Miosge, Lisa ;
Barthel, Nadine ;
Teh, Charis E. ;
Roots, Carla M. ;
Bull, Katherine R. ;
Jeelall, Yogesh ;
Horikawa, Keisuke ;
Whittle, Belinda ;
Balakishnan, Bhavani ;
Sjollema, Geoff ;
Bertram, Edward M. ;
Mackay, Fabienne ;
Rimmer, Andrew J. ;
Cornall, Richard J. ;
Field, Matthew A. ;
Andrews, T. Daniel ;
Goodnow, Christopher C. ;
Enders, Anselm .
JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (01) :31-40
[6]   THE CTLS KISS OF DEATH [J].
BERKE, G .
CELL, 1995, 81 (01) :9-12
[7]   Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations [J].
Campbell, Kerry S. ;
Purdy, Amanda K. .
IMMUNOLOGY, 2011, 132 (03) :315-325
[8]  
Chatzidimitriou D, 2012, FUTURE MICROBIOL, V7, P1217, DOI [10.2217/FMB.12.87, 10.2217/fmb.12.87]
[9]   Regulation of NK cell activity by 2B4, NTB-A and CRACC [J].
Claus, Maren ;
Meinke, Stephan ;
Bhat, Rauf ;
Watzl, Carsten .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2008, 13 :956-965
[10]   Hidden talents of natural killers: NK cells in innate and adaptive immunity [J].
Cooper, Megan A. ;
Colonna, Marco ;
Yokoyama, Wayne M. .
EMBO REPORTS, 2009, 10 (10) :1103-1110