2,8-Diheterobicyclo[3.2.1]octane Ring Systems: Natural Occurrence, Synthesis and Properties

被引：7

作者：

Flores, MariFe ^{[1
]}

Diez, David ^{[1
]}

机构：

[1] Univ Salamanca, Fac Ciencias Quim, Dept Quim Organ, E-37008 Salamanca, Spain

来源：

SYNLETT | 2014年 / 25卷 / 12期

关键词：

alkaloids; bicyclic compounds; cycloaddition; natural products; imines; CONTAINING CARBONYL YLIDES; CYCLOADDITION REACTIONS; 1,3-DIPOLAR CYCLOADDITION; ASYMMETRIC EPOXIDATION; BIOCHEMICAL-PROPERTIES; CYTOTOXIC METABOLITES; SELECTIVE GENERATION; CIRCULAR-DICHROISM; SQUALENE SYNTHASE; TANDEM REACTIONS;

D O I：

10.1055/s-0033-1339132

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This account describes the developments on the synthesis and reactivity of functionalized 2,8-diheterobicyclo[3.2.1]octanes. The continued interest in the chemistry of these compounds is mainly due to their abundance in Nature, being at the core of numerous families of biologically active natural products, and also as a result of their versatile reactivity, which makes them very useful building blocks with considerable impact in modern organic synthesis. The present article is aimed toward providing a comprehensive coverage of the literature on these heterocyclic scaffolds, including our own contributions, and has been organized according to the nature of the heteroatom embedded in the 2,8-bicyclo[3.2.1]octane framework.

引用

页码：1643 / 1666

页数：24

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