Cyclooxygenases: structural and functional insights

被引：501

作者：

Rouzer, Carol A.

Marnett, Lawrence J. ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, AB Hancock Jr Mem Lab Canc Res, Dept Biochem, Nashville, TN 37232 USA

来源：

JOURNAL OF LIPID RESEARCH | 2009年 / 50卷

基金：

美国国家卫生研究院;

关键词：

prostaglandin; endocannabinoid; inflammation; nonsteroidal anti-inflammatory; coxib; hydroperoxide; arachidonic acid; essential fatty acid; ENDOPEROXIDE-H SYNTHASE-1; IN-VIVO; COX-2; INHIBITION; INFLAMMATION; MICE; LIPOPOLYSACCHARIDE; OXYGENATION; ACTIVATION; EXPRESSION;

D O I：

10.1194/jlr.R800042-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclooxygenase (COX; prostaglandin G/H synthase, EC 1.14.99.1) catalyzes the first two steps in the biosynthesis of prostaglandins (PGs). The two COX isoforms COX-1 and COX-2 are the targets of the widely used nonsteroidal anti-inflammatory drugs, indicating a role for these enzymes in pain, fever, inflammation, and tumorigenesis. The ubiquitous constitutive expression of COX-1 and inducible expression of COX-2 have led to the widely held belief that COX-1 produces homeostatic PGs, while PGs produced by COX-2 are primarily pathophysiological. However, recent discoveries call this paradigm into question and reveal as yet underappreciated functions for both enzymes.jlr This review focuses on some of these new insights.-Rouzer, C. A., and L. J. Marnett. Cyclooxygenases: structural and functional insights. J. Lipid Res. 2009. S29-S34.

引用

页码：S29 / S34

页数：6

共 45 条

[1] Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2 [J].