Innovative strategy with potential to increase hemodialysis efficiency and safety

被引：43

作者：

Chen, Hsiao-Chien ^{[1
]}

Lin, Hsiu-Chen ^{[2
,3
]}

Chen, Hsi-Hsien ^{[4
,5
]}

Mai, Fu-Der ^{[1
,6
]}

Liu, Yu-Chuan ^{[1
,6
]}

Lin, Chun-Mao ^{[1
]}

Chang, Chun-Chao ^{[4
,7
]}

Tsai, Hui-Yen ^{[1
]}

Yang, Chih-Ping ^{[8
]}

机构：

[1] Taipei Med Univ, Coll Med, Sch Med, Dept Biochem, Taipei 11031, Taiwan

[2] Taipei Med Univ, Sch Med, Dept Pediat, Coll Med, Taipei 11031, Taiwan

[3] Taipei Med Univ Hosp, Dept Lab Med, Taipei 11031, Taiwan

[4] Taipei Med Univ, Sch Med, Dept Internal Med, Coll Med, Taipei 11031, Taiwan

[5] Taipei Med Univ Hosp, Div Nephrol, Dept Internal Med, Taipei 11031, Taiwan

[6] Taipei Med Univ, Biomed Mass Imaging Res Ctr, Taipei 11031, Taiwan

[7] Taipei Med Univ Hosp, Div Gastroenterol & Hepatol, Dept Internal Med, Taipei 11031, Taiwan

[8] Taipei Med Univ, Grad Inst Med Sci, Coll Med, Taipei 11031, Taiwan

来源：

SCIENTIFIC REPORTS | 2014年 / 4卷

关键词：

VAPOR GENERATION; WATER; ANTIOXIDANT;

D O I：

10.1038/srep04425

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3Fe(CN)(6) in saline solution can be significantly increased from 2.76, to 4.62 x 10(-6) cm s(-1), by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.

引用

页数：5

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