Long non-coding RNA bladder cancer-associated transcript 2 contributes to disease progression, chemoresistance and poor survival of patients with colorectal cancer
被引:7
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作者:
Ren, Yongjun
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机构:
North Sichuan Med Coll, Affiliated Hosp, Sichuan Key Lab Med Imaging, Dept Intervent Radiol, 63 Wenhua Rd, Nanchong 637000, Sichuan, Peoples R ChinaNorth Sichuan Med Coll, Affiliated Hosp, Sichuan Key Lab Med Imaging, Dept Intervent Radiol, 63 Wenhua Rd, Nanchong 637000, Sichuan, Peoples R China
Ren, Yongjun
[1
]
Zhao, Caixia
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机构:
Nanchong Cent Hosp, Dept Oncol, Nanchong, Sichuan, Peoples R ChinaNorth Sichuan Med Coll, Affiliated Hosp, Sichuan Key Lab Med Imaging, Dept Intervent Radiol, 63 Wenhua Rd, Nanchong 637000, Sichuan, Peoples R China
Zhao, Caixia
[2
]
He, Yi
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机构:
North Sichuan Med Coll, Dept Gastrointestinal Surg, Nanchong 637000, Sichuan, Peoples R ChinaNorth Sichuan Med Coll, Affiliated Hosp, Sichuan Key Lab Med Imaging, Dept Intervent Radiol, 63 Wenhua Rd, Nanchong 637000, Sichuan, Peoples R China
He, Yi
[3
]
Xu, Hao
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机构:
North Sichuan Med Coll, Affiliated Hosp, Sichuan Key Lab Med Imaging, Dept Intervent Radiol, 63 Wenhua Rd, Nanchong 637000, Sichuan, Peoples R ChinaNorth Sichuan Med Coll, Affiliated Hosp, Sichuan Key Lab Med Imaging, Dept Intervent Radiol, 63 Wenhua Rd, Nanchong 637000, Sichuan, Peoples R China
Xu, Hao
[1
]
Min, Xuli
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机构:
North Sichuan Med Coll, Affiliated Hosp, Sichuan Key Lab Med Imaging, Dept Intervent Radiol, 63 Wenhua Rd, Nanchong 637000, Sichuan, Peoples R ChinaNorth Sichuan Med Coll, Affiliated Hosp, Sichuan Key Lab Med Imaging, Dept Intervent Radiol, 63 Wenhua Rd, Nanchong 637000, Sichuan, Peoples R China
Min, Xuli
[1
]
机构:
[1] North Sichuan Med Coll, Affiliated Hosp, Sichuan Key Lab Med Imaging, Dept Intervent Radiol, 63 Wenhua Rd, Nanchong 637000, Sichuan, Peoples R China
[2] Nanchong Cent Hosp, Dept Oncol, Nanchong, Sichuan, Peoples R China
[3] North Sichuan Med Coll, Dept Gastrointestinal Surg, Nanchong 637000, Sichuan, Peoples R China
bladder cancer-associated transcript 2;
metastasis;
proliferation;
drug resistance;
prognosis;
EXPRESSION;
D O I:
10.3892/ol.2019.10487
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Colorectal cancer (CRC) is one of the leading causes of cancer-associated mortality worldwide. Long non-coding RNAs (lncRNAs) have been revealed to modulate various biological cell processes, and are involved in the initiation and progression of different diseases, including CRC. However, the role of lncRNA bladder cancer-associated transcript 2 (BLACAT2) in CRC has not been defined. The present study aimed to investigate the role of BLACAT2 in CRC. The present study measured the expression levels of BLACAT2 in CRC cells and tissues by reverse-transcription-quantitative polymerase chain reaction, and associations among BLACAT2 expression levels, important clinicopathological parameters and patient survival were statistically evaluated. The functional role of BLACAT2 in metastasis, proliferation and drug resistance was also detected. BLACAT2 was overexpressed in CRC cells and tissues, and high BLACAT2 expression was associated with larger tumor size, and more advanced lymph node (N), metastasis (M) and tumor-NM stages. Additionally, survival analysis demonstrated that patients with high BLACAT2 expression exhibited poor overall survival. Notably, high BLACAT2 expression was identified as an independent risk factor for overall survival. Migration and invasion assays revealed that BLACAT2 promoted migration and invasion, respectively. In addition, overexpression of BLACAT2 increased colony numbers and optical density values of CRC cells in a colony formation assay and an MTT assay, respectively. Furthermore, BLACAT2 levels were significantly increased in 5-fluorouracil-resistant cells, and overexpression of BLACAT2 was markedly associated with a low cell inhibition rate. In conclusion, BLACAT2 overexpression may contribute to the metastasis, proliferation and chemoresistance of CRC cells, and high BLACAT2 expression may be a promising prognostic marker for patients with CRC.
机构:
Jilin Univ, Dept Cardiol, China Japan Union Hosp, Changchun, Jilin, Peoples R ChinaJilin Univ, Dept Cardiol, China Japan Union Hosp, Changchun, Jilin, Peoples R China
Yang, Yushuang
Yang, Wei
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机构:
Changchun Sixth Hosp, Dept Psychol, Changchun, Jilin, Peoples R ChinaJilin Univ, Dept Cardiol, China Japan Union Hosp, Changchun, Jilin, Peoples R China
Yang, Wei
Jin, Ling
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机构:
Jilin Univ, Dept Clin Lab, China Japan Union Hosp, 126 Xiantai Rd, Changchun 130033, Jilin, Peoples R ChinaJilin Univ, Dept Cardiol, China Japan Union Hosp, Changchun, Jilin, Peoples R China
机构:
Second Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R China
Liu, Anwei
Zhang, Zhensheng
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机构:
Second Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R China
Zhang, Zhensheng
Xu, Weidong
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机构:
Second Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R China
Xu, Weidong
Qin, Shengfei
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机构:
Second Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R China
Qin, Shengfei
Hua, Meimian
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机构:
Second Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R China
Hua, Meimian
Zeng, Shuxiong
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机构:
Second Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R China
Zeng, Shuxiong
Xu, Chuanliang
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机构:
Second Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Changhai Hosp, Dept Urol, 168 Changhai Rd, Shanghai 200433, Peoples R China
机构:
Univ Fed Ouro Preto, Programa Posgrad Ciencias Farmaceut CIPHARMA, Ouro Preto, MG, BrazilUniv Fed Ouro Preto, Programa Posgrad Ciencias Farmaceut CIPHARMA, Ouro Preto, MG, Brazil
Braga Lima, Ana Paula
da Silva, Glenda Nicioli
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机构:
Univ Fed Ouro Preto, Programa Posgrad Ciencias Farmaceut CIPHARMA, Ouro Preto, MG, Brazil
Univ Fed Ouro Preto, Programa Posgrad Ciencia Biol CBIOL, Ouro Preto, MG, Brazil
Univ Fed Ouro Preto, Dept Anal Clin DEACL, Escola Farm, Ouro Preto, MG, BrazilUniv Fed Ouro Preto, Programa Posgrad Ciencias Farmaceut CIPHARMA, Ouro Preto, MG, Brazil