Tualang honey supplement improves memory performance and hippocampal morphology in stressed ovariectomized rats

被引：46

作者：

Al-Rahbi, Badriya ^{[1
]}

Zakaria, Rahimah ^{[1
]}

Othman, Zahiruddin ^{[2
]}

Hassan, Asma ^{[3
]}

Ismail, Zul Izhar Mohd ^{[3
]}

Muthuraju, Sangu ^{[4
]}

机构：

[1] Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Kubang Kerian 16150, Malaysia

[2] Univ Sains Malaysia, Sch Med Sci, Dept Psychiat, Kubang Kerian 16150, Malaysia

[3] Univ Sains Malaysia, Sch Med Sci, Dept Anat, Kubang Kerian 16150, Malaysia

[4] Univ Sains Malaysia, Sch Med Sci, Dept Neurosci, Kubang Kerian 16150, Malaysia

来源：

ACTA HISTOCHEMICA | 2014年 / 116卷 / 01期

关键词：

Ovariectomy; Social instability stress; Novel object recognition test; Hippocampus; Estrogen; Tualang honey; Rat; ESTROGEN-REPLACEMENT THERAPY; CONJUGATED EQUINE ESTROGENS; RADICAL SCAVENGING ACTIVITY; MILD COGNITIVE IMPAIRMENT; OBJECT RECOGNITION MEMORY; ACTIVATED PROTEIN-KINASE; CHRONIC RESTRAINT STRESS; POSTMENOPAUSAL WOMEN; HORMONE REPLACEMENT; CHOLINE-ACETYLTRANSFERASE;

D O I：

10.1016/j.acthis.2013.05.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recently, our research team has reported that Tualang honey was able to improve immediate memory in postmenopausal women comparable with that of estrogen progestin therapy. Therefore the aim of the present study was to examine the effects of Tualang honey supplement on hippocampal morphology and memory performance in ovariectomized (OVX) rats exposed to social instability stress. Female Sprague-Dawley rats were divided into six groups: (i) sham-operated controls, (ii) stressed sham-operated controls, (iii) OVX rats, (iv) stressed OVX rats, (v) stressed OVX rats treated with 17 beta-estradiol (E2), and (vi) stressed OVX rats treated with Tualang honey. These rats were subjected to social instability stress procedure followed by novel object recognition (NOR) test. Right brain hemispheres were subjected to Nissl staining. The number and arrangement of pyramidal neurons in regions of CA1, CA2, CA3 and the dentate gyrus (DG) were recorded. Two-way ANOVA analyses showed significant interactions between stress and OVX in both STM and LTM test as well as number of Nissl-positive cells in all hippocampal regions. Both E2 and Tualang honey treatments improved both short-term and long-term memory and enhanced the neuronal proliferation of hippocampal CA2, CA3 and DG regions compared to that of untreated stressed OVX rats. (C) 2013 Elsevier GmbH. All rights reserved.

引用

页码：79 / 88

页数：10

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