Synthesis and characterization of a fluorescent adenosine derivative for detection of intermolecular RNA G-quadruplexes

被引：17

作者：

Kim, In Sun ^{[1
]}

Seo, Young Jun ^{[1
]}

机构：

[1] Chonbuk Natl Univ, Dept Chem, Jeonju 561756, South Korea

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 08期

关键词：

RNA; G-quadruplex; Oligonucleotide; Fluorophore; Intermolecular; REPEAT-CONTAINING RNA; ELECTRON-TRANSFER; C-MYC; DNA; PYRENE; TELOMERES; TRANSCRIPTION; REGION; TRANSLATION; NUCLEOSIDE;

D O I：

10.1016/j.tetlet.2014.01.048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We synthesized a fluorescent adenosine derivative, rA(PY), as a probe to study RNA structural transitions, in particular the intermolecular G-quadruplex formation. rA(PY) was incorporated into the dangling positions of guanine-rich oligonucleotides, which under physiological conditions undergo pi-stacking on top of each other exhibiting a strong emission signal in their G-quadruplex conformation, but not in their single-stranded state. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1461 / 1463

页数：3

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